EDUCATION

This change will revolutionize the hemp industry, including CBD products, which had been living in a legal gray area for decades. Some regulations were eased with the 2014 Farm Bill, but it was still very difficult for CBD companies like us to follow the guidelines, as many were left up to interpretation.

With the 2018 Farm Bill, hemp farmers are going to have the ability to participate in USDA programs for certifications for competitive grants, therefore, will also be able to have certifications such as “organic” with the new law. This is something our industry truly needs as we have seen a flood of bad products entering the market in recent months. 

HOW FEDERAL LAW REGARDING HEMP AND CBD HAS EVOLVED

Even before the 2018 Farm Bill went into effect, hemp and CBD have long presented unique opportunities for business growth in the United States. Hemp is a fast-growing, easily-cultivated variety of the Cannabis sativa L. plant with many commercial uses, such as textile products and food. Marijuana is a different variety of the Cannabis sativa L. plant and contains high concentrations of tetrahydrocannabinol (THC), the chemical that produces psychoactive effects. In contrast, hemp by definition contains minimal concentrations of THC. CBD is a different compound derived from the Cannabis sativa L. plant (either marijuana or hemp varieties) with numerous putative health and general wellness benefits. 

Despite the fact that neither hemp nor hemp-derived CBD contain significant amounts of THC, until December 20, 2018, hemp was categorized as a Schedule I substance under the Controlled Substances Act, the main federal criminal law regarding prohibited drugs, alongside narcotics such as heroin. As such, it was generally illegal at the federal level to cultivate, possess or distribute the hemp plant or CBD derived from the hemp plant, although certain inert portions of the Cannabis sativa L. plant (hemp or marijuana), such as the stalks or non-germinating seeds, could be bought or sold. 

Moreover, federal regulations enforced by the Drug Enforcement Agency (DEA), the lead agency responsible for federal criminal drug enforcement, forbade products intended for human consumption that contain any portion of the cannabis plant, including the inert portions otherwise exempted from the Controlled Substances Act. See 21 C.F.R. § 1308.35. This effectively made CBD products, regardless of how derived, illegal at the federal level. 

Nevertheless, hemp and CBD businesses have thrived in numerous state jurisdictions in which such products are legal. These businesses have operated in a quasi-legal status under U.S. Department of Justice policy, which has effectively permitted otherwise legitimate industry related to cannabis to operate in state jurisdictions where such business is legal and well-regulated. 

Regulations enforced by the Food and Drug Administration (FDA) present additional, non-criminal legal concerns for the sale of hemp-derived CBD products. Some manufacturers and marketers of CBD-infused products—including food, beverages, dietary supplements and creams—claim that the products are effective in the treatment and prevention of various diseases. The FDA has taken the position that such claims subject the products to regulation as drugs, which typically requires prior approval from the FDA based upon clinical trials to establish product safety and efficacy. The FDA has issued a number of warning letters over the past three years to halt the marketing of products for which such claims are made, although no enforcement actions have followed. 

There are two other concerns arising from FDA regulation. First, in June 2018 the FDA approved a prescription drug for the treatment of seizure disorders that contains CBD as the active ingredient. Under federal law, a food may not include an approved drug, such as CBD, without further FDA approval. Second, as a new ingredient in food, it is important that the safety of CBD for human consumption be established before a food product containing it may be put on the market. 

THE 2018 FARM BILL

On December 12, 2018, Congress passed the 2018 Farm Bill, which was signed into law by President Trump the following week. Importantly, the bill includes key text regarding hemp that was championed by Senate Majority Leader Senator Mitch McConnell (R-KY) with strong bi-partisan backing:

• The 2018 Farm Bill defines hemp as the plant Cannabis sativa L. and any part of the plant with a delta-9 THC concentration of not more than 0.3 percent by dry weight. This definition is consistent with the definition of “industrial hemp” in the 2014 version bill, which created a limited agricultural pilot program regarding research into industrial hemp.
• The 2018 Farm Bill removes hemp from the Controlled Substances Act, paving the way for the wholly legal cultivation, possession, sale and distribution of the hemp plant.
• The 2018 Farm Bill delegates to states and Indian tribes the broad authority to regulate and limit the production and sale of hemp and hemp products within their borders. States and Indian tribes cannot, however, limit the transportation or shipment of hemp and hemp products through their respective jurisdictions.

Consequences of the 2018 Farm Bill to the Hemp and CBD Industries

In 2017, U.S. retail sales for products containing hemp, including food and beverage products, personal care products, household products, and supplements, reached $820 million. Based on current demand, forecasters project hemp and CBD to be a $1 billion industry by 2020. This year’s passage of the 2018 Farm Bill will certainly boost hemp and CBD production and sales.

Federal legalization means that hemp producers and businesses that deal in hemp and hemp-derived products, such as CBD, are now free to pursue their businesses more aggressively, and with less concern that a seismic shift in enforcement priorities could result in their investigation or prosecution by federal authorities. Following passage of the 2018 Farm Bill, CBD producers, in particular, will have much greater incentive to use hemp as their primary source for CBD (rather than marijuana). It is still important, however, that businesses involved in the hemp industry comply with state and federal regulations regarding legalized hemp, and that businesses selling CBD (including food and beverages) stay clear of the aggressive health-related marketing that may result in unwanted attention from the FDA and carefully navigate the other health and food regulatory issues implicated by FDA oversight.

THE HISTORY OF HEMP PROHIBITION

Hemp prohibition dates back to 1906, where many believe newspaper publisher William Randolph Hurst started the smear campaign against hemp. People believe that Hearst felt this was a threat to his extensive timber holdings, and thus his newspaper was used to share false facts around hemp. This helped lead to the misunderstanding that hemp and marijuana are the same, which they are not.

Ultimately, the charge for hemp and cannabis prohibition was led by Harry Anslinger, a government official who served as the first commissioner of the U.S. Treasury Department’s Federal Bureau of Narcotics. He was a supporter of prohibition and the criminalization of drugs and played a pivotal role in cannabis prohibition.

The Marihuana Tax Act of 1937 was one of the first steps America made in the crackdown on hemp plants. The Tax Act of 1937 was eventually repealed by Leary v. United States in 1969.

In the next year, the Controlled Substances Act was passed, which the new 2018 Farm Bill successfully overrules. This was a replacement for the Marihuana Tax Act of 1937 and placed hemp as a controlled substance.

CBD OIL AND THE 2018 FARM BILL 

Under the 2018 Farm Bill, hemp is considered an agricultural product and will thus open the floodgates for research and development, not only with hemp but derivatives such as CBD and other cannabinoids. CBD oil will be studied now like never before. We are so excited to follow the latest research and bring that information to you as we get it.

At Made By Hemp, we will also be participating in our own research and development with CBD oil and hemp as bringing you the highest quality hemp oil products is the most important thing to us.

HIGHLIGHTS OF THE 2018 FARM BILL 

If you would like to read the entire 807 page report be our guest, otherwise, below are the main points highlighted by attorney Jonathan Miller from Frost Brown Todd LLC:

“The era of hemp prohibition is over.  Hemp is now permanently removed from the Controlled Substances Act (CSA).  It is forever deemed an agricultural commodity, no longer mistaken as a controlled substance, like marijuana.

• By redefining hemp to include its “extracts, cannabinoids and derivatives,” Congress explicitly has removed popular hemp products — such as hemp-derived cannabidiol (CBD) — from the purview of the CSA. Accordingly, the Drug Enforcement Administration no longer has any possible claim to interfere with the interstate commerce of hemp products. This should give comfort to federally regulated institutions — banks, merchant services, credit card companies, e-commerce sites, and advertising platforms — to conduct commerce with the hemp and hemp product industry.
• Hemp farmers now may finally access needed crop insurance and can fully participate in USDA programs for certification and competitive grants.
• State and Tribal governments may impose separate restrictions or requirements on hemp growth and the sale of hemp products – however, they cannot interfere with the interstate transport of hemp or hemp products. We are hopeful that local and state officials will follow Congress’ lead, as well as the statements and resolutions of the World Health Organization and the U.S. Food and Drug Administration (FDA) that declare, after intense scientific scrutiny, that CBD is safe, non-toxic, and non-addictive.
• The FDA continues to exercise jurisdiction over the regulation of ingestible and topical hemp products.  We applaud the agency’s continued efforts to crack down on bad actors who undermine the industry through misguided marketing claims.  And while we are concerned about non-binding statements made by the FDA that have led some state and local officials to question the legality of the retail sale of hemp-derived CBD, we are hopeful that we can work with the agency to clarify that CBD – which their own scientists concluded has no abuse potential and does not pose a risk to public health – should not be withheld from Americans who count on it for their health and wellness.

SECTION BY SECTION 

• Section 7129 (p. 313): Includes hemp in USDA’s supplemental and alternative crops programs. Section 7501 (p. 338): Includes hemp in USDA’s critical agricultural materials programs.
• Section 7605 (p. 347): Orders the USDA Secretary to prepare a report on the 2014 Farm Bill pilot program, and then repeals that program one year after the new permanent hemp program is created. Section 10113 (p. 429): The guts of the new permanent legalization regime:
• Section 297A (p. 429) Defines hemp as all parts of the plant less than 0.3% THC, including “derivatives,” “extracts” and “cannabinoids.”
• Section 297B (p. 429) Empowers states and Tribes to submit plans to USDA to implement a permanent hemp growing program.  Requires information gathering, testing, and inspection procedures.  The USDA Secretary must sign off on, or reject, the plan within 60 days, and consult with the Attorney General.  The Secretary can later audit state programs and work with the states to develop corrective action plans where there is noncompliance.
• Section 297B(e)(p. 431): Orders states and Tribes to develop procedures to address violations, including corrective action in the case of negligence.
• Section 297B(e)(3)(B) (p. 432): Individuals who commit drug felonies cannot participate in state or Tribal growth programs for 10 years following the date of their conviction.  However, participants in the 2014 Farm Bill pilot programs are grandfathered in to participate in permanent programs despite any prior felony committed.
• Section 297C (p. 432): States and Tribes are required to maintain information on lands where hemp is grown and testing, enforcement and inspection procedures.  The USDA Secretary must collect such information to be accessible in real time to local, state and federal law enforcement.
• Section 297D (p. 434): The USDA Secretary is required to submit an annual report to Congress on the program’s implementation.
• Section 297D(c)(p. 434): Nothing in the new law affects the FDA’s authority under the Food, Drug, and Cosmetic Act or the Public Health Service Act.
• Section 10114 (p. 435): Nothing in the act prohibits the interstate commerce of hemp, nor can States or Tribes prohibit the transportation of hemp or hemp products through their territory.
• Title XI (p. 439):  Hemp farmers are made eligible for crop insurance, and marketability requirements for the crop insurance program can be waived.
• Section 12619 (p. 540): Hemp is removed from the definition of “marihuana,” and THC found in hemp is excluded from the definition of a controlled substance.”

SACRAMENTO, Calif. (May 24, 2019) – On Wednesday, the California Assembly unanimously passed a bill that would allow the legal sale of food and food additives containing CBD within the state. This will not only open up markets in California, but it is also a crucial step given the FDA’s continued prohibition of the same.

Assm. Cecilia Aguiar-Curry (D-Winters) introduced Assembly Bill 228 (AB228) on Jan. 17. Under the proposed law, a food, beverage, or cosmetic would not be considered adulterated by the inclusion of industrial hemp or cannabinoids, extracts, or derivatives from industrial hemp. In effect, this would prohibit state restrictions on the sale of food, beverages, or cosmetics that include industrial hemp or cannabinoids, extracts, or derivatives from industrial hemp.

On May 22, the Assembly passed AB228 by a 77-0 vote.

Enactment of AB228 would end state prohibition on the sale CBD and CBD products based on federal law. This is crucial because despite removing the plant from the list of controlled substances late last year, the federal government still prohibits the sale of CBD products under FDA rules.

Last summer, the California Department of Health declared that CBD-infused food, drink and dietary supplements cannot be sold by retailers that are not licensed under the state’s medical marijuana law. According to the department, the state must follow federal law.

“Although California currently allows the manufacturing and sales of cannabis products (including edibles), the use of industrial hemp as the source of CBD to be added to food products is prohibited. Until the FDA rules that industrial hemp-derived CBD oil and CBD products can be used as a food or California makes a determination that they are safe to use for human and animal consumption, CBD products are not an approved food, food ingredient, food additive, or dietary supplement.” [Emphasis added]

The state has been attempting to enforce the ban as well. The Associated Press reported that California health inspectors raided Johnathan Eppers’ Los Angeles warehouse and impounded about $100,000 worth Vybes, a popular CBD oil-infused beverage. Eppers told the AP that about 50 California retailers dropped the product and he moved his production facilities to Texas.

Despite enforcement efforts and limited negative impacts, CBD-infused products remain widely available in California. Final passage of AB228 would end state enforcement completely by deeming CBD safe for human and animal consumption, and ending state prohibition of CBD products.

2018 Farm Bill and CBD

With the passage of the farm bill, the federal government now treats industrial hemp as an agricultural commodity instead of a controlled substance. While the DEA will no longer have the authority to regulate hemp, the provisions of the farm bill have no bearing on FDA rules and regulations regarding CBD. In fact, a section in the farm bill makes this explicit.

Section 297D, paragraph (c)(1) “Regulations and Guidelines; Effect on Other Law” states “nothing in this subtitle shall affect or modify the Federal Food, Drug, and Cosmetic Act.”

Practically speaking, the passage of the farm bill does not mean CBD will now be federally-legal in all 50 states, as some hemp supporters claim. In fact, the FDA still maintains a strict prohibition on the sale of CBD in the U.S.

To date, the FDA has only approved one medication with cannabidiol as an active ingredient – Epidiolex for the treatment of seizures. But the FDA classifies CBD as “a drug for which substantial clinical investigations have been instituted.” Under federal law, that designation means the FDA maintains full control over the substance and it cannot be marketed as a “dietary supplement.” The agency maintains that the sale of CBD or any food products containing the substance is illegal.

To date, the agency hasn’t changed its position on CBD. In a recent congressional hearing, former FDA Commissioner Scott Gottlieb said he understands that Congress wants a pathway to CBD availability, but said “it is not a straightforward issue” due to the fact that the agency has approved CBD for treatment of epilepsy and it is ““subject of substantial clinical investigation.” Both of these factors prohibit CBD from being sold as a “health supplement” and from being added to food.

Gottlieb said, “the law does allow us to go through a regulatory process and go through a notice and comment rule-making to establish a framework to allow it to be put into the food supply.” He said the first step would be a public meeting “sometime in April”

In effect, the agency can continue to enforce these same rules even with the passage of the 2018 farm bill. While farmers can now legally grow hemp for commercial purposes, including the production of fiber, biofuel, building products, paper, clothes and even food products that don’t contain CBD, the sale of cannabinol or food products containing CBD remain federally-illegal, as it has been all along, unless the FDA changes its policy or Congress passes legislation specifically legalizing CBD.

IN EFFECT

With the passage of AB228, California would not interfere with the sale of CBD products regardless of continued federal prohibition. And without state cooperation, the FDA would likely have trouble regulating it in California.

Despite past and ongoing federal prohibition, CBD is everywhere. A New York Times article asserted that “with CBD popping up in nearly everything — bath bombs, ice cream, dog treats — it is hard to overstate the speed at which CBD has moved from the Burning Man margins to the cultural center. 

This was happening when both the DEA and FDA prohibited CBD. It will undoubtedly continue as long as market demand remains and states don’t interfere. The FDA can’t effectively enforce prohibition without the assistance of state and local officials. In fact, state regulation hasn’t even stopped the sale of CBD products in California. 

According to the FDA, the agency prioritizes enforcement based on a number of factors, including “agency resources and the threat to public health. FDA also may consult with its federal and state partners in making decisions about whether to initiate a federal enforcement action.”

Even with both the FDA and DEA theoretically enforcing federal laws and regulations banning CBD, state and local action have already nullified federal prohibition in practice and effect. There’s no reason to think that won’t continue as long as states maintain the same stance on CBD as they did under the 2014 farm bill. Simply put, the federal government lacks the personnel and resources to crack down on CBD – even if the FDA wants to. 

For more information please visit: https://blog.tenthamendmentcenter.com/2019/05/california-assembly-passes-bill-to-allow-sale-of-cbd-products-despite-fda-prohibition/

Cannabidiol—CBD—is a cannabis compound that has significant medical benefits but does not make people feel “stoned” and can actually counteract the psychoactivity of THC. The fact that CBD-rich cannabis is non-psychoactive or less psychoactive than THC-dominant strains makes it an appealing option for patients looking for relief from inflammation, pain, anxiety, psychosis, seizures, spasms, and other conditions without disconcerting feelings of lethargy or dysphoria.

Cannabidiol, also known as CBD is the name of one of the numerous compounds found in the cannabis plant. Cannabinoids are a class of active chemical compounds produced by the cannabis plant that are found throughout the seeds, stalk, and flowers of cannabis plants — including hemp and marijuana. These cannabinoids act on receptors located in our cells as part of the endocannabinoid system (ECS) and alter the release of neurotransmitters from body organs, including the brain. The ECS predominantly consists of two endocannabinoid receptors: CB1, located in the central nervous system (CNS), and CB2, found throughout the peripheral nervous system (PNS). Researchers are currently discovering new receptors and are now uncovering that there may be more CB receptors inside of our body.

CBD is the main active compound in hemp and unlike THC, CBD it is not psychoactive, so it does not make you high. Hemp plants have substantial amounts of CBD and only trace amounts of THC which has led to it becoming more popularly recognized for its medicinal purposes. Researchers have been able to identify numerous therapeutic uses of CBD. CBD hemp oil is a natural botanical concentrate.

Scientific and clinical research—much of it sponsored by the US government—underscores CBD’s potential as a treatment for a wide range of conditions, including arthritis, diabetes, alcoholism, MS, chronic pain, schizophrenia,  PTSD, depression, antibiotic-resistant-infections, epilepsy, and other neurological disorders.

CBD has demonstrable neuroprotective and neurogenic effects, and its anti-cancer properties are currently being investigated at several academic research centers in the United States and elsewhere. Further evidence suggests that CBD is safe even at high doses. Inside the human body there’s the endocannabinoid system, with receptors spread throughout the brain and body. Cannabinoid receptors are involved in a series of processes inside the human body, including the regulation of mood, pain sensation, appetite and memory. These receptors can be activated by endocannabinoids produced by the human body as well as by plant cannabinoids and they’re grouped in two main categories: CB1 and CB2. CB1 receptors are found mostly in the central nervous system, and in smaller numbers in the liver, kidneys and lungs, while CB2 receptors are part of the immune system and found in the hematopoietic blood cells as well [1]. It used to be thought that CBD acts on these CB2 receptors, but it appears now that CBD does not act on either receptor directly. Instead, it seems to influence the body to use more of its own cannabinoids. It has been shown that Cannabidiol (CBD) strengthens and improves the efficacy of mitochondria, the power source for every cell in your body.

Continued studies on the Endocannabinoid System (ECS) have shown that apart from being regulator of homeostasis, the ECS also responsible for repairing damaged cells. Research has also shown that cannabinoids are able to target damaged cells without affecting normal cells, which means that the ECS can act as a biological defense system. When a person ingests hemp oil, CBD, or other cannabinoids, these cannabinoid receptors are activated (CBD seems to have a higher affinity for CB2 receptors than CB1 receptors). Research is showing that supplementing your Endocannabinoid System with plant cannabinoids, you are naturally developing a healthier ECS system and improving the power source of your body’s cells.

Johnson, Jon. (2017, April). CBD oil: Uses, health benefits, and risks. Retrieved from www.medicalnewstoday.com

Source: Article published by Medical News Today; Reviewed by Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT

There are several reasons people seek out alternative solutions to manage their pain. One reason is opioid addiction is on the rise. According to the National Institute on Drug Abuse, more than 49,000 Americans died from opioid use in 2017. Over the counter pain relievers like Tylenol can also have negative side effects such as nausea, stomach pain and liver damage. That isn’t the case for the compound found in hemp known as CBD. It’s a natural, non-addictive, non-toxic and alternative way to treat pain that has been used for thousands of years.

CBD has the ability to aid those suffering from several ailments, and it’s even useful for healthy people in everyday living. As users continue to report its beneficial therapeutic effects, it’s fair to say that hemp-derived CBD is good for the human body.

CBD BENEFITS

CBD oil has skyrocketed in popularity because of the benefits it brings, including:

• Pain Relief
• Quitting Smoking and Withdrawals
• Digestive Assistance
• Improves Mood Disorders
• Reduces Anxiety and Depression
• Helps with Epilepsy
• Lowers Inflammation

Please note that these are commonly listed benefits of CBD Oil, and that we do not make any promises as to your experience or outcomes.

CBD VERSUS THC CHART

Check out this chart to see all of the benefits of CBD Oil and compare those to THC. In addition to these benefits, CBD Oil can actually counteract some of the anxiety caused by THC itself.

CBD treats the whole body. You won’t feel a sudden change when taking CBD oil, as you might taking some prescribed medication. Most people report an overall feeling of wellbeing. If you have some arthritis, for example, and take some CBD oil, you might not notice until you suddenly realize you don’t have the pain. It is a subtle feeling and gets better with repeated use.

The endocannabinoid system is thought to play an important role in the immune response of our skin. An improper immune response can result in inflammation and this is why CBD is being researched as an anti-inflammatory for inflammation related skin conditions. Other important functions of the endocannabinoid system in the skin include regulation of cell growth and wound healing. Both CB1 and CB2 receptors have been found throughout the skin.

Are there side effects of using CBD on the skin?

CBD and cannabis skin products are generally safe to apply liberally to the skin and are not likely to cause side effects. Even if the product contains THC, psycho-activity is not likely with this delivery method. However, it is very important you test a small amount on your skin first before applying liberally to the affected area. Allergic reactions have occurred, and you need to test yourself to see if you are allergic. It’s also not recommended to use CBD skin products which contain alcohol as this could make some skin conditions worse.

If you do have an allergic reaction, it may not necessarily be an allergic reaction to CBD or one of the cannabinoids. Instead, you may be having an allergic response to an additive in the product you are using. Check product labels and try to find products which only contain CBD, cannabinoids, and the base that acts as the carrier – i.e. coconut oil or hempseed oil.

HOW SHOULD I USE CBD ON MY SKIN?

Always speak with a doctor before using CBD, especially if you already take other medications. CBD can cause drug interactions. However, you are likely do not need to worry about drug interactions when only using CBD topically, but we always recommend speaking with your doctor.

After making sure you are not allergic, you can liberally apply CBD salve, lotion or cream to any place you have pain or skin irritation. People with arthritis pain have reported fast relief by applying cannabinoid rich topical products directly to an inflamed and painful joint. CBD  molecules absorbed through the skin will interact with cells that are near the surface without ever entering the bloodstream.  CBD salve or cream is ideal for those looking for isolated pain relief or to address skin conditions because it can be applied directly to where you may need it the most. Human skin, in general, has low permeability, which means it blocks most substances from entering. The skin has a particularly low absorption rate for cannabinoids, however, when applied liberally, CBD is permeable to the skin through its pores.

The way you choose to ingest CBD molecules or apply CBD molecules onto your body, will determine the absorption rate and whether; CBD molecules will enter into your blood stream.

In general, there are four primary methods for CBD consumption.

The one that works best for you may differ depending on your circumstances. Tinctures can be taken sublingually, added to food and drinks and rubbed directly on your skin, concentrates and vape oil are either used with a pin or smoked through a vape pen, edibles eaten and topicals applied directly to the sore spot.

• Sublingual, placed under the tongue
• Ingestion
• Topical
• Inhalation
• (Injection) But strongly rare, and not recommended

Some ingestion methods work faster than others. Thousands of studies suggest that CBD interacts with receptors throughout the body to create balancing and healing effects. However, for CBD to have influence over our systems, this natural non-psychoactive compound first needs to be absorbed into the bloodstream where it can then be transported throughout the body to interact with our cannabinoid receptors CB1 and CB2, and non-cannabinoid receptors. CBD absorption depends on how it’s consumed. This can influence how effective the cannabinoid treatments will be.

SUBLINGUAL METHOD

Liquid emulsions are a popular way to consume hemp-derived CBD because of the faster onset of action due to the product entering the bloodstream orally. Sublingual administration through the mouth is the most common way to take CBD oil. Taking CBD oil under your tongue and holding it there for 60 seconds sends the molecule directly into your bloodstream. When CBD oil is administered sublingually, it should be held under the tongue so that the mucus membranes in the mouth can absorb the oil’s active ingredients.

With the correct dose, you’ll feel relief within 45 minutes to an hour, maybe sooner. The benefit of consuming CBD oil sublingually is that the absorption process bypasses the digestive system and liver metabolization, allowing the compounds to reach your bloodstream and interact with the endocannabinoid system more quickly.

INGESTION METHOD

Another common way to take CBD oil is to ingest it orally. When you ingest CBD oil, it is absorbed through the digestive system and is metabolized by the liver, eventually sending its active compounds to your bloodstream. This form of administration is exactly how vitamins and other daily supplements are most typically taken. Common ingestible CBD oil products include edibles, capsules, and beverages. Capsules can be easily swished down with a mouthful of water and are among one of the easiest ways to take CBD.  

CBD oil can be infused into a wide variety of edibles and beverages, including coffee. Ingestion, while considered by most to be the easiest administration method, isn’t necessarily the most efficient for absorbing high levels of CBD unless you are consuming CBD with fatty acids that can help bypass the metabolism to increase how much CBD is absorbed through ingestion.

TOPICAL METHODS

Some CBD oil products are designed to be applied directly onto the skin in the form of lotions and salves. These products are more applicable for potentially addressing pain or serious skin issues and are designed to be applied directly onto the skin. CBD is absorbed through the skin so that it can interact with cells that are near the surface without ever entering the bloodstream.  CBD salve or cream is ideal for those looking for isolated pain relief or to address skin conditions because it can be applied directly to where you may need it the most.

Human skin, in general, has low permeability, which means it blocks most substances from entering. The skin has a particularly low absorption rate for cannabinoids, however, when applied liberally, CBD is permeable to the skin through its pores.

Some oils get absorbed quickly because they contain a lot of Polyunstaturated acids: Omega 3 (alpha-linolenic acid) and Omega 6 fatty acids (linoleic acid and gamma-linoleic acid).  Oils that contain at least 50% of polyunsaturated acids get absorbed very fast.

INHALATION METHODS

CBD can also be inhaled by vaporizing. Vaporizing CBD is typically a consumption option recommended for adults. The compounds are absorbed through the alveoli in the lungs, which offer a large absorptive surface area. A vaporizer heats CBD oil just enough to release its active compounds, avoiding the harmful byproducts that are created with combustion.

During vaporization, CBD enters your lungs and diffuses directly into your bloodstream. Because it doesn’t have to make its way through the digestive system or liver, the CBD enters your circulation faster. Also, less CBD is lost during vaporizing compared to the ingestion method.  The CBD molecules are immediately transferred into the bloodstream. Compared to ingestion, the inhalation method allows more CBD to be absorbed and offers faster absorption.

CBD oil products designed for vaporization include CBD e-liquid, which contains CBD oil infused with vegetable glycerin (VG), MCT oil or combination of VG and Propylene Glycol (PG) plus high-CBD concentrate. Vaporizers range in size from tabletop, plug-in powered units to small, battery-powered portable pens. 

The endocannabinoid system in the human body is responsible for maintaining homeostasis, which enables all systems and organs to function optimally together including physiological processes – which is why CBD also works well in treating emotional and mental imbalances. Each time you have an ailment or condition, whether it is the common cold or cancer, it is likely that this is a result of an instability within the endocannabinoid system.

When we are talking about CBD in  general here , we are only about Industrial Hemp-Derived CBD.  CBD molecule is such an effective and safe medicine for dozens of diseases, including fatal conditions such as epilepsy. This is because CBD molecule works so well in responding to the endocannabinoid system. More people are taking CBD  as a form of prevention against disease and to keep the endocannabinoid system. By consuming or using CBD infused products regularly and following these tips, you can ensure that your endocannabinoid system is in top shape – and reduce your risk for disease:

Stress management: Stress is one of the biggest culprits of both mental and physical diseases. Find ways of coping with stress in natural ways; perhaps you can combine cannabis with a yoga and meditation practice, or exercise more often. Engage in creative and artistic activities to get your mind off the problem. These ways will help you manage stress naturally and calm you down.

Omega-6 and Omega-3 fatty acids: Both of these acids aren’t produced naturally by the human body although they have significant health benefits, which is why we have to consume them from external sources such as certain varieties of fish or fish oil supplements. Both omega-6 and omega-3 fatty acids share similar therapeutic benefits as the cannabinoids found in CBD, so making sure that you get enough of these fatty acids will double your chances of fighting inflammation, a root cause of many disorders including cancer and heart disease.

Nutrition: Forget about the latest trends in “superfoods”; everything you need to keep yourself healthy and your endocannabinoid system in balance boils down to one simple thing: fresh and organic produce. There’s no need to shell out so much money on cold-pressed juices and the latest fads in healthy eating (by all means if you can afford it, go ahead); but just by consuming more greens and fresh fruit will do you good. Certain herbs and spices such as nutmeg, saffron, and turmeric contain potent therapeutic benefits that can aid in stimulating the endocannabinoid system, similar to the way CBD does. Avoid foods that cause inflammation such as refined sugar and flour, red meat, and excessive dairy. Make healthy choices when you get the munchies!

Sun exposure: Too much sun exposure without proper SPF protection will increase your risk for skin cancer, but a few minutes of good morning sun a day can help boost your endocannabinoid system. Studies show that sun exposure has a way of increasing cannabinoid receptors since UVA rays are a powerful inducer of nitric oxide, which has been shown to increase abundance of CB1 receptors in animal models.

Exercise: Integrating cannabis with your fitness routine is now becoming more common, as people are increasingly learning the benefits of CBD when it comes to fitness and even weight loss. Exercise helps your body get rid of harmful toxins, reduces stress, supports heart health, reduces inflammation, and helps you sleep better.

Probiotics: Found in yogurt, kombucha, and other foods, probiotics is one of the foods that can help regulate the endocannabinoid Probiotics can increase CB2 receptors found in the intestinal cells, which can help keep stomach disorders at bay.

Reduce alcohol intake: Drinking too much alcohol has been shown to reduce the efficacy of cannabinoid signaling in the body, which also means that it may dampen the sensitivity of cannabinoid receptors. Most of us enjoy a good alcoholic drink once in a while, but if you want to prevent disease or are already suffering from an ailment, limit your alcohol consumption.

Take cold showers regularly: No matter what kind of climate you live in, an occasional cold shower has been shown to stimulate the cannabinoid system, a process called thermogenic activation. Aside from that, it can also be relaxing especially when you alternate it with hot water for a truly invigorating bath.

Cannabis plants (Indica, Sativa and Hybrid) contain both THC and CBD compounds.  But unlike CBD, THC produces a psychoactive effect which is commonly used for recreational purposes.  However, CBD is more so used for the medicinal qualities it offers and is not psychoactive effects like THC. CBD oil can be made from both marijuana and hemp.

Industrial Hemp based (Hemp-Derived) CBD oils, when used in low doses, are unlikely to result in a positive test because they often do not contain high enough levels of THC for detection. Companies that require their employees to submit mandated drug screenings are generally checking for specific recreational drugs. 

These tests usually specifically test for THC and other control substances.   Interestingly, recent research seems to back up the position that CBD is not a drug in this sense that it is not normally detected during a drug screening. Most U.S. employers, for instance, abide by the guidelines set forth by the Substance Abuse and Mental Health Services Administration (SAMHSA), which includes detection for THC but not for CBD. Most employment drug tests specifically look for the presence of THC or THC metabolites, but it is highly unlikely that CBD oil will show up on a drug test. 

But you would fail a drug test from using CBD alone: “If an employee is using hemp-derived CBD oil, they would have to consume above 1000-2000mg of the product, considered a relatively large amount, to test non-negative. Taking that much CBD oil could result in the user’s impairment”   Even though CBD does not trigger a positive result on your drug test, it is possible that certain products contain trace amounts of THC. THC could build up in your system enough to trigger a positive on a drug test.

Always read the label: To protect yourself at your best, always know if the products you are using are made from cannabis derived Marihuana or Industrial Hemp-Derived. “Cannabidiol (CBD) derived from Industrial Hemp  with content of 0.3% THC OR NDT THC shouldn’t show up on a drug test. However, keep in mind that many CBD products contain trace amounts of delta-9-tetrahydrocannabinol (THC) as their main active ingredient. To be safe, make sure; you read the label before use/consume any CBD Product(s).  If enough THC is present, it will show up on a drug test.

That being said, it is important to note that CBD products that contain THC could potentially cause someone to fail a screening, but CBD isolate compounds are available to avoid that concern. In general, drug tests do not test for CBD. CBD is not on the list of “A Controlled Substance” But,  your very own safety, if you worry about drug interactions and  drug testing is your concern, and you must take drug tests regularly, you should not use any CBD Product.

Yes, they are. Terpenes are non-psychoactive, and while they are commonly used to enhance the high associated with cannabis use, they do not cause it. Instead, the psychoactive effects of marijuana are caused by THC, which works to activate the CBD 1 and 2 receptors in the brain.

Organic terpenes; pronounced tur-peens are metabolites that are found in the oils of most plants and even some insects. There are over 23,000 different terpenes in existence. The cannabis plant alone has at least 100 different terpenes. Terpenes have many incredible benefits for the body and mind, and they are also what gives cannabis its unique aroma and flavor.

Despite common misconception, terpenes are not exclusive to the cannabis plant. In fact, they are naturally occurring compounds that are found in plant life and in some insects.  The confusion stems from the recent popularity of adding terpene profiles and isolates to cannabis. This causes different effects for the user, including a longer lasting, and more powerful high. It can also impact the effects of cannabis in terms of the type of high. While recreational marijuana is not legal in every state, terpene use is. In fact, you can now purchase pure terpene isolates or profiles and add them to your favorite drink, food, or incorporate the terpenes in your next aromatherapy session.

There are thousands of terpenes that are derived from plant life. While we may not know much about many of them, we have learned quite a bit about the two hundred terpenes that naturally occur in cannabis. Now that you know terpene use is legal, let’s find out how terpenes can impact your high, the chemical effects of terpene use and what types of health benefits terpenes offer.

Terpenes are organic aromatic hydrocarbon molecules that are formed by some insects and all plant life. They’re also the primary components in essential oils and plant resins. These volatile compounds are meant to ward off harmful bacteria and fungus and protect plants from environmental stresses. They also work as basic chemical building blocks for more complex molecules, such as cannabinoids. Their aroma is one of their most notable attributes. They emit a pungent aroma and are responsible for the scent and flavor of cannabis. Most cannabis users know that a wide range of scents can be detected from each strain of marijuana. This is because there are more than two hundred different types of terpenes in cannabis. The scent of cannabis is determined by the most dominate terpenes in a particular strain.

There are over fifty thousand terpenes globally, with two hundred found in the cannabis plant alone. Terpenes can heavily influence both the taste and fragrance of food, beverages, and even cannabis. This ultimately depends on terpene type and content. Some food will have a stronger or milder taste based on the types of dominate terpenes it contains and the same goes with cannabis.

Since recent studies have discovered that adding certain types of terpenes can positively impact cannabis quality in terms of the strength, and duration of your high, and the effects, terpene use is now more popular than ever. But before this discovery, most people had never even heard the word terpene. So, it comes as no surprise that many people mistakenly believe that terpenes are only found in cannabis. But as we mentioned, terpenes are found in all plant life, and even in some insects. These powerful naturally occurring components can have a major positive impact on your health, but they’re more widely known for their ability to affect a cannabis user’s high in a variety of ways.

Cannabis is packed with several powerful terpenes including:

• B-caryophyllene
• Caryophyllene oxide
• Linalool
• Phytol
• Nerolidol
• Myrcene

Each of these terpenes can impact the type of high you experience, whether it brings you up, boosting energy, or brings you down, promoting sedation and relaxation. But these terpenes are all fragrance and flavor components that are common in the human diet. This means that there are many ways you can safely and easily utilize their benefits without smoking or vaping cannabis. In their plain form, terpenes can also offer some impressive therapeutic effects.

Terpenes are what contribute to the flavor and scent of many foods, but they also offer many unique health benefits. As an example, linalool, which is found in lavender, is a terpene that’s also found in and added to cannabis due to its power as an antidepressant, sedative, and analgesic pain reliever. It’s also commonly used for its anti-seizure, and anti-anxiety benefits. Because of this, linalool is often found in candles and essential oils that are used for aromatherapy and marketed as calming. It can also be found in lotions, body sprays, and some solvents.

So – why do terpenes matter?

1. They directly affect your high and contribute to The Entourage Effect of cannabis
2. They have medical benefits
3. They give cannabis and vape oil its natural flavor

A few common terpenes and their effects:

Myrcene:

The most common terpene in cannabis. It is also known as the “couch-lock” terpene for its highly-sedative effects.

Limonene:

Common in citrus, it is highly-energetic and a known antidepressant.

Terpinolene:

A smokey or woody aroma that is slightly sedative, antioxidant, anti-cancer and antibacterial.

Beta-Caryophyllene:

Gastroprotective and a strong anti-inflammatory with a woody, peppery taste.

Alpha and Beta-Pinene:

Energetic and therapeutic, this terpene is common in pine needles. If you’ve ever walked through a forest and felt “lifted” you’ve experienced this terpenenoid!

Humulene:

The main constituent of hops is a strong anti-inflammatory agent and a hunger-suppressant.

Are Terpenes Good for You?

Yes, they are. They offer many health benefits when used correctly. Currently, preclinical studies are underway to study the effects of terpenes on cancer cells, and while we don’t know the full scope of their potential to naturally eliminate cancer cells, the results thus far are very promising. The powerful terpene limonene has been shown to prevent cancer cells from spreading and can even prevent cancer cells from forming. Another powerful terpene called B-caryophyllene has been found to suppress tumor growth and can cause cancer cell death. It can also act like a cannabinoid, activating the CB2 endocannabinoid receptors in the brain. Linalool is often used to promote relaxation, but it also contains anticonvulsant properties. Research has shown that linalool use can impact the main excitatory neurotransmitters in the brain that initiate seizure activity. Additionally, terpenes are commonly used to help people suffering from insomnia, anxiety, depression, and chronic pain and inflammation. As we learn more about terpenes and how they can impact the different systems in the body, it’s clear that terpene use will increase in the near future.

So why do we add terpenes into topical products?

Entourage Effect: How Do Terpenes Impact CBD Wellness Products?

Research about what terpenes can do for users of cannabis is still limited, to an extent; marijuana is still illegal on a federal level, making it hard for researchers to study it. What research is available, though, suggests a lot of promising effects.

“A lot of what the research out there is showing is that CBD on its own tends to be less effective than CBD in conjunction with smaller amounts of THC and other cannabinoids, and the terpenes that you find in cannabinoids,” said Kris Krane, president of medical cannabis brand development and advising company 4Front Ventures. “It’s the entourage effect of the different cannabinoids and terpenes that tends to be most effective.”

That “entourage effect,” as it is generally known, refers to terpenes reacting synergistically with cannabinoid compounds like THC in the endocannabinoid system (neurotransmitters and cannabinoid receptors found in most mammals’ nervous systems) in order to affect the body and mind.

Should a terpene have physical effects, the effect will depend on the specific terpene. Terpenes with similar aromas may have similar effects. Overall, terpenes may be able to provide physical effects that include:

• Anti-inflammatory properties
• Pain relief
• Antibacterial properties
• Antifungal properties
• Assistance with muscle spasms

In addition, other terpenes may be able to help with the mental impact of issues such as:

• Depression
• Anxiety
• Insomnia
• Stress

There are known to be over 200 terpenes found in the cannabis plant. Terpenes may be a new term for you, but chances are, you’ve had some interactions with them.  Terpenes refer to the compounds found in the essential oils of a plant and are most prominent in citrus and conifer trees. It’s the scent you pick up when the wind blows through a rose garden. It’s the smell you inhale when breaking up rosemary stalks. It’s also that strong aroma you get standing in a dense pine forest.

Many herbs, fruits, vegetables and flowers contain terpenes. Originally the development of terpenes in the plant world was to ward off predators and entice pollinators, but they have come to serve a bigger purpose, especially in the cannabis plant. The importance of terpenes in CBD infused wellness products is crucial. Adding terpene rich essential oils to whole plant extracted cannabis oil results in a symphony, each ingredient working in harmony.

Terpenes are organic hydrocarbon compounds found in a variety of plants. These compounds are secreted in the form of oils that give off distinct aromas and flavors. Think lavender or citrus. We all know and appreciate the aromatic properties of these plants.  But more importantly than tantalizing our senses and  well-being, they are little power houses that help fight against disease and imbalance in our bodies.  When it comes to topical application of CBD infused wellness products with various cannabinoids , certain terpenes have a profound effect on the way chemicals are transported across skin barriers, making cannabinoids such as CBD & THC more readily available (Bioavailability)  to cannabinoid receptors found within our bodies.

Just like CBD & THC, terpenes themselves readily absorb into the body carrying with them many therapeutic properties. These cannabinoids have the ability to interact with the body’s very own endocannabinoid system, providing both analgesic and anti-inflammatory responses. The bodies largest organ, the skin, contains millions upon millions of cannabinoid receptors making topical CBD wellness product for pain an extremely effective tool. Each terpene is unique in that they absorb differently depending on the vehicle in which they are applied.

Cannabinoids work better in groups, as do terpenes. Some terpenes, like limonene, even aid in the absorption of other terpenes. So. it’s really a “the more the merrier” type of situation. A lot of people have had  great success with these products, whether for therapeutic or medicinal uses.  Terpenes have their own pain-relieving benefits.

When combined, CBD wellness products with terpenes helps to alleviate pain and inflammation, helping you to live a more active and comfortable life. The more terpenes the greater the synergistic effects. Terpenes provide not only aromatic qualities to CBD but also have their own unique health benefits. Terpenes have the ability to magnify the therapeutic benefits of a plant’s individual components.  When added to CBD wellness products, terpenes help to achieve the entourage effect, helping your body to maximize the benefit it has on your body, by enhancing the absorption of  topical CBD wellness products into skin with heightened therapeutic relief. Terpenes themselves have the ability to bind to cannabinoid receptors which helps CBD & THC penetrate the skin barrier, further enhancing the beneficial effects of these compounds.

• D-Limonene– It’s been shown to elevate mood, relieve stress, and has anti-fungal and antibacterial properties. It also improves absorption of other terpenes and other substances through the skin, which makes it great if use for tinctures, ointments, and other topicals for pain management products. (citrus): Like its name suggests, limonene smells like lemons.

• Myrcene– This terpene enhances the feeling of relaxation and can provide increased stress-relief. It can compose up to 50 percent of a cannabis plants terpenes. Myrcene has also been shown to be useful as an anti-inflammatory, a sedative, and a muscle relaxer. Myrcene can be found in mangoes, hops, thyme, lemongrass, and basil, and is the most commonly found terpene in cannabis. (earthy, musky, fruity)

• Linalool(floral, spicy)-Linalool is found in flowers and spices like lavender and coriander, and is widely known for its stress-relieving, anti-inflammatory, and anti-depressant effects. The linalool terpene balances out the anxious side effects of THC, which makes it a useful treatment of both anxiety and psychosis. Some studies also suggest that linalool can boost the immune system and significantly reduce lung inflammation.

• Humulene (hoppy, earthy): Humulene is found in hops, coriander, cloves, and basil. It’s best known for its anti-inflammatory properties and its ability to suppress appetite (while many other strains only increase appetite).

• Caryophyllene (peppery, spicy): Caryophyllene is found in Thai basils, cloves, cinnamon leaves and black pepper. Studies show that it can help treat anxiety, depression, and act as an anti-inflammatory, which sounds like a big job to handle for one small terpene.

• Terpinolene (smoky , woodsy): Terpinolene can be found in sage and rosemary, and has slightly sedative, antioxidant, and antibacterial properties. It’s also been found to depress your central nervous system, and therefore induce drowsiness and reduce excitement or anxiety.

• Curcumin: From the Turmeric plant, curcumin is bright yellow and is what gives our 4% and 6% their vibrant color. It’s a powerful Anti-inflammatory and anti-oxidant

• Pinene(pine): Pinene is the most common terpene in the world, and has anti-inflammatory properties. It’s also found in orange peels, pine needles, basil, and parsley. It’s been known to counter short-term memory loss from THC, improve airflow to your lungs, and promote alertness.

• Beta-Caryophyllene: Is a versatile terpene isolate with a sweet and dry taste that is commonly found in allspice.including black pepper, basil, and oregano, and cannabis strains with high levels of it deliver a spicy, funky warmth to the nose, similar to cinnamon and cloves. This stress-relieving terpene is known to cause relaxation and reduce anxiety. Studies on caryophyllene indicate a wide variety of therapeutic potential with pain-relieving properties. Caryophyllene has also been shown to have antioxidant and anti-inflammatory properties, and to be a possible therapy for treating inflammatory bowel disease. Research has even found that caryophyllene may be able to treat anxiety and depression. Current studies are hoping to unveil even more of the therapeutic potential behind caryophyllene, including research indicating that it may help with lifespan longevity by reducing gene stress.

Copaiba Extract – Powerfully relaxing, Copaiba oil comes from a fragrant tropical tree native to South America. Copaiba oil can help soothe anxious feelings and supports the cardiovascular, nervous, digestive, immune, and respiratory systems. With a pleasant, spicy, and woody aroma, Copaiba oil can help calm emotions and soothe anxious feelings. It is a wonderful oil to turn to at the end of a stressful day. The oil also contains powerful antioxidants that boost immune health. Copaiba oil is a well-loved oil because it relieves discomfort and promotes overall health, supporting people to feel and live their best. 

Just like CBD-Copaiba is rich with Beta-caryophyllene; is also a potent anti-inflammatory agent and copaiba is one of the safest oils to use on the skin. It can be very useful in healing, soothing irritation and treating chronic skin disease. Among those wonderful Amazonian oils that benefit skin is copaíba, an oil that comes from the resin of the copaifera reticulata tree which grows in Brazil and other South American countries.

Unlike many of the other oils and butters we’ve been featuring lately, copaíba oil doesn’t come from a seed or nut but rather from the lifeblood (sap) of a tree. It has wonderful anti-inflammatory and acne-fighting properties; making it a wonderful treatment for infection, skin conditions, and muscular/skin pain relief. It’s actually considered to be one of the most anti-inflammatory substances on Earth!

The most impressive health benefits of copaiba essential oil include its ability to reduce pain and inflammation, ease headaches, protect against infections, heal the skin, prevent fungal growth, and boost respiratory health. It can also be used to improve the health of the skin and hair, maintain bladder control, boost healing, tighten the skin, and lower blood pressure.

Copaiba is considered to be one of the most anti-inflammatory substances on earth, yet much of the world only uses copaiba as a lacquer or varnish. In traditional medicine, this essential oil has been used extensively by indigenous people and is now spreading around in the world. The active components in copaiba essential oil are quite powerful, consisting mainly of terpenes, which are hydrocarbons that have significant effects on the functioning of our body. Fortunately for us, most of the side effects of the terpenes found in copaiba essential oil are very beneficial for our health.

Beta-caryophyllene is a natural chemical that occurs in some essential oils and is thought to be one of the most anti-inflammatory chemical constituents, thus considered an analgesic substance that can help to reduce pain and loosen muscles. The highest known essential oil source for beta-caryophyllene is Copaiba oil which generally has a beta-caryophyllene level of 50-60%. Copaiba, Black Pepper, Clove, and Ylang Ylang have significant amounts of beta-Caryophyllene. Many people use these essential oils for general inflammation and discomfort support. 

Beta-caryophyllene is also a common and often abundant terpene found in cannabis. Its distinctive flavor contributes to the spiciness of black pepper and can be found in high amounts in cloves, hops, and rosemary. It falls under the FDA’s “generally recognized as safe” classification, so large doses can be safely consumed. Over the last decade, β-caryophyllene has gained the attention of scientists when it was discovered to be one of the first non-cannabinoids to directly activate cannabinoid receptors. Beta-caryophyllene-rich cannabis strains may therefore have specific medicinal effects due to this terpene’s effect on our endocannabinoid system.

The Potential Benefits of β-Caryophyllene

CB2 receptors are found in immune tissues throughout the body and are increased in the brain in disease or following injury. Their activation reduces inflammation, which lessens pain and reduces the damaging consequences that chronic inflammation has on brain function and risk for developing brain diseases.

Research on β-caryophyllene is somewhat limited. On one hand, it’s tempting to generalize the therapeutic benefits of β-caryophyllene based on the effects of other compounds that activate CB2 receptors. After all, CB2 receptor activation by other compounds can play an important role in reducing pain, preventing seizures, and even decreasing plaque buildup in the arteries.

But not all activators of CB2 receptors have the same effect. Differences in the specific way that β-caryophyllene activates CB2 receptors can lead to differences in the strength of therapeutic effects.

Pain

The data suggest that, in many cases, β-caryophyllene can provide pain relief. In one study, scientists injected mice with β-caryophyllene and found that they experienced less pain than those treated with the control solution. Furthermore, β-caryophyllene enhanced the pain-reducing strength of low-dose morphine. This could be one reason why those using prescription opioids from pain are often able to decrease their dose of opioids when they begin using medical cannabis.

For more details, please visit: https://www.leafly.com/news/strains-products/benefits-of-high-caryophyllene-cannabis-strains-for-pain

Regarding awesome remedies for pain relief, DMSO is the General Patton of pain relievers. DMSO is the ultimate OTC pain reliever. You probably have not heard of DMSO. DMSO stands for dimethyl sulfoxide. This solvent is a by-product of the wood industry and has been commercially available since 1953.

DMSO can be extracted from oil, coal, or most commonly lignin. DMSO was first synthesized in 1866 by the Russian chemist Alexander Saytzeff. The medical benefits of DMSO were first discovered in 1961 by Dr. Stanley Jacob (graduate of Ohio State University Medical School & Harvard University Medical School; 1st Place Recipient German Science Award, 1965) while he was the director of the organ transplant program at Oregon Health Sciences University. While studying DMSO’s potential for preserving organs, Dr. Jacob found that DMSO quickly & deeply penetrated skin without damaging the tissues. As his studies continued, he discovered that DMSO, among other properties, quickly relieved pain and inflammation.

During the mid 1960s the FDA ,in a controversial move, banished the medical prescription of DMSO (in contrast to 125 other countries). In 125 countries, including Germany, Great Britain, Canada, & Japan, physicians prescribe DMSO for treating a wide array of ailments, including inflammation, pain, interstitial cystitis, scleroderma, & arthritis-elevated intercranial pressure. However, in 1978 the FDA did approve DMSO for prescriptive use in treating interstitial cystitis (a painful inflammatory disease of the bladder & urinary tract).

Over 40,000 technical articles have been published regarding DMSO’s chemistry. Globally, an estimated 11,000 articles have been published on DMSO’s clinical & medical implications. Multiple books have been written on DMSO and it’s benefits. The abundance of research & technical studies suggest that DMSO is non-toxic & safe for use. 

By U.S. law, it cannot be prescribed by nor recommended by a physician in most states. Only 8 U.S. states have effectively bypassed the authority of the FDA because their respective state legislatures have legalized the prescribing of DMSO. Said states are Florida, Louisiana, Montana, Nevada, Oklahoma, Oregon, Texas and Washington. It is available as a liquid, gel, & roll-on sold as a solvent. Regarding pain relief, one simply dabs DMSO onto the skin. Over the years private consumers have used it as a topical pain relief medication for pulled, strained, and sprained muscles and joints. By law, we must issue the following statement (you will find this message or a similar one on the actual product labels): DMSO is sold as a solvent only. DMSO is intended for use as a solvent only. The choice of the process used in the various applications is the sole responsibility of the user.

If you suffer from arthritis pain, joint pain, back pain, knee pain, etc., you owe it to yourself to investigate & try DMSO in the treatment of your pain and/or inflammation.

DMSO is used topically to decrease pain and speed the healing of wounds, burns, and muscle and skeletal injuries. DMSO is also used topically to treat painful conditions such as headache, inflammation, osteoarthritis, rheumatoid arthritis, and severe facial pain called tic douloureux. It is used topically for eye conditions including cataracts, glaucoma, and problems with the retina; for foot conditions including bunions, calluses, and fungus on toenails; and for skin conditions including keloid scars and scleroderma. 

When applied topically, DMSO is quickly absorbed into the deeper tissues. When mixed with other substances, DMSO can also enhance the absorption of that substance. In addition to being a spectacular carrier, it also has anti-inflammatory characteristics that can help relieve joint and muscle pain, but also have the ability to dissolve any impurity into the deepest lay of skin and blood stream. Therefore, always use DMSO infusion products with caution and keep you’re your skin/ apply area clean.

Studies have indicated that DMSO’s capacity of a free-radical scavengerplays an important role in its effects on arthritis. The Committee of Clinical Drug Trials of the Japanese Rheumatism Association conducted a trial with 318 patients and concluded that DMSO both relieved joint pain and increased range of motion and grip strength. DMSO is still used widely around the world for various types of arthritis.

DMSO is natural pain reliever. DMSO is classified as a nonsteroi- -dal anti-inflammatory drug (NSAID), just like phenylbutazone (“bute”). Unlike bute, however, DMSO controls inflammation primarily by acting as an antioxidant.

Since aspirin, DMSO was the first anti-inflammatory substance that is not a steroid to be discovered. Terry Bristol, a Ph.D. candidate from the University of London and president of the Institute for Science, Engineering, Public Policy in Portland, Oregon, who assisted Dr. Jacob with his research in the 1960s and 1970s believes that it was this discovery that caused pharmaceutical companies to try to develop other non-steroidal anti-inflammatories.

Although DMSO can relieve both acute and chronic arthritis pain, DMSO is known to work best in acute forms. DMSO is used to try to help treat arthritis because of its anti-inflammatory properties because it reduces autoimmune antibodies, and it prevents free radicals from destroying lubricating fluid in the joints.

DMSO is also rich in sulfur, which plays a role in the formation of muscle, skin, hair, and nails as well as cartilage which is made up of collagen. Studies have shown that degenerative arthritis can cause less than normal levels of sulfur in cartilage.

People have been known to use DMSO for acute conditions by applying it every two hours for 6-8 hours immediately after an injury, and then applying DMSO every 4-6 hours for the next five days or more. Most report that most benefit from DMSO occurs in the first three weeks.

As for chronic conditions, DMSO has been known to take longer to take effect. Some notice some pain relief right away, although it may take 6-8 weeks or, some have reported, even six months to a year for the maximum benefit to be achieved, depending on the person and what they are using DMSO for.

DMSO enhances diffusion of other chemicals through the skin, for this very reason, it is very important to always clean your hands and the affected area before applying any DMSO topicals. It is important to wash your hands and under your nails thoroughly before using topical DMSO. You should always clean the area you plan to apply DMSO, just in case there is some harmful substance on your skin with a molecule small enough to be carried through the skin. 

DMSO is easily absorbed by the skin. It’s sometimes used to increase the body’s absorption of other medications and intensifying the effects. DMSO is available without a prescription most often in gel or cream form. It can be purchased in health food stores, by mail order, and on the Internet.

Test Patches: Temporary skin irritation is normal with products content DMSO, so before the first use, apply it to a small area on your forearm to test your skin sensitivity so you know what to expect. Your skin may tingle after topically applying DMSO. In some instances, people have reported experiencing a slight smell and/or taste of garlic after applying DMSO topically. To reduce skin irritation, allow the DMSO to be absorbed for a few minutes (5-20 depending on your sensitivity) and then wipe off any excess. If irritation persists, rinse with cool water and discontinue to use immediately. Contact your physician if irritation persists.

Warning: Pregnant women, breastfeeding women, & diabetic patients should not use DMSO unless under the advice of their physician. Discuss the use of DMSO with your family physician. However, do not be surprised if your physician has not heard of DMSO. You may have to educate them regarding DMSO. Some side effects of taking DMSO by mouth or applying it to the skin may include skin reactions, burning sensation, dry skin, headache, dizziness, drowsiness, nausea, vomiting, diarrhea, constipation, breathing problems, vision problems, blood problems, and allergic reactions. DMSO also causes a garlic-like taste, and breath and body odor.

REFERENCES:

The DMSO Handbook: A New Paradigm in Healthcare, Authors: Dr Hartmut Fischer & Dr Seiriol Dafydd; Publisher: Daniel-Peter-Verlag; First English Edition (December 17, 2015). ISBN-10: 3981525558, ISBN-13: 978-3981525557.

DMSO: Nature’s Healer, Author: Morton Walker D.P.M.; Publisher: Avery Publishing Group Inc.; Later Printing Edition (January 1, 1993). ISBN-10: 0895295482, ISBN-13: 978-0895295484.

The Persecuted Drug: The Story of DMSO, Author: Pat McGrady Sr; Publisher: Charter Communication; 7TH. PRINTING, 1980 Edition (1980). ISBN-10: 0441151019

ISBN-13: 978-0441151011.

The Balm Was Banned in ’65, but Now ‘Wonder Drug’ DMSO Stirs a Booming Black Market, Author: Maria Wilhelm; Publisher: People Magazine; January 26, 1981. URL: https://people.com/archive/the-balm-was-banned-in-65-but-now-wonder-drug-dmso-stirs-a-booming-black-market-vol-15-no-3/

Interview with Dr. Stanely Jacob, Author: Linda Weimer; Publisher: Oregon Health Sciences University History Department; September 24, 1998.

Dimethyl Sulfoxide: Compound that Doctors Are Calling a Medical Miracle, Author: Danica Collins; Publisher: Underground Health Reporter; June 7, 2011.

DMSO: Many Uses, Much Controversy, Author: Maya Muir; Publisher: DMSO.org; Date unknown.

Doctor Stanley Jacob: The Father of DMSO; Publisher: DMSO.org; Date unknown.

Pharmacology of DMSO, Authors: Stanley W. Jacob & Robert Herschler, Department of Surgery, Oregon Health Science University, Portland, Oregon 97201; Publisher: Academic Press, Inc.; September 16, 1985, pp. 14-27.

Physical Properties of Dimethyl Sulfoxide and Its Function in Biological Systems; Author: H. Harry Szmant, Department of Chemistry, University of Detroit, Detroit, Michigan 48221.

The Human Toxicology Of Dimethyl Sulfoxide, Author: Richard D. Brobyn, Bainbridge Medical Center Bainbridge Island, Washington.

CBD MASSAGE BENEFITS AND FAQ

The hottest buzz in the spa world is the benefits of infused CBD products and massages. CBD is Non-Psychoactive and Anti-inflammatory. Massage creams and oils infused with CBD, are inherently therapeutic for the mind and the body. Massage therapist and patients alike can reap these soul soothing benefits of an infused massage.  

What role does CBD play in the massage?

The anti-inflammatory and pain-relieving agents of CBD reduces inflammation within muscles and joints, allowing the massage therapist to work more effectively. People seek massages as a way to relax and escape stress. For athletes, CBD also has the reputation for accelerating the recovery and healing process of injured connective tissue.

How CBD works?

The CBD receptors (known as CB2) are part of the endocannabinoid system, which is the physiological system that helps the homeostatic functions within the central nervous system. This includes maintenance of bodily functions, pain, inflammation, and the immune system.

CB2 receptors are found in nerve and immune cells in just about every organ. CBD binds to CB2 receptors as well as TRPV1 receptors. Damaged tissues sensitize TRPV1 to its chemical and physical stimuli. Adding massage further benefits the stimulation of TRPV1 activity and has a positive influence on the CB2 receptors, which helps alleviate inflammation and pain.

CBD topicals are one of the most therapeutic ways to benefit from these amazing botanicals.  Our unique formula is blended in small batches so that clients receive maximum benefits. A wonderful combination of CBD hemp and other botanicals including pure essential oils to enhance its therapeutic benefits.

CBD Massage Treatment-A powerful anti-inflammatory that helps to relieve pain. Not only will you receive the benefits from your therapeutic massage, when you incorporate these amazing botanicals, it becomes the ultimate massage experience. Chronic Pain -Studies have shown cannabis is highly effective at lowering all types of pain, including the pain that’s shown to be resistant to other treatments. 

Other benefits of CBD Massage Include*:

• Relaxes muscle spasms and tension
• Alleviates neuropathic pain 
• Anti-inflammatory
• Reduces Migraine Pain
• Fibromyalgia-Studies have shown cannabis effectively lowers pain levels and improves quality of sleep in patients. 
• Better sleep at night

CBD Massage FAQ

What is a CBD Massage like? 

This massage is tailored to your needs. Our clinical massage therapist will customize a treatment according to how you feel when you come in. Whether your focus is deep relaxation, relief from pain or both. Instead of using a massage lotion (which has no therapeutic value) we will apply our own CBD infused formulation to the muscles to provide the benefits listed above.

Where do get your cannabis from?

Our Organic CBD Extract Hemp Massage Oil  is sourced from hemp grown in USA, free of pesticides, herbicides, or chemical fertilizers.

Will I get high?

No, there is no psychoactive effect to any of our products.

Will my massage therapist or I get high from this treatment?

No! CBD is the non-psychoactive compound of the cannabis plant. Even with low levels of THC, there is no high and subjects being drug tested after a CBD massage have tested negative for THC which is why professional athletes use these products.

Yes, try a CBD message and experience the benefits!

It’s important to discuss these common questions and misconceptions to further the development of medicinal cannabis and its positive benefits. Relationships such as massage therapy and cannabis are just the beginning of cannabis’s role in our everyday health.

Is it legal?

Our Organic CBD Hemp Massage Oil is legal in the State of California and in all states that permit the usage of CBD Oil. Our Massage Oil content  LESS THAN 0.03% NDT THC.

How much is a CBD massage?

The treatment costs $90 – $300 and focuses on adjusting imbalances in the body. Clients can take the rest of CBD home afterward.

Quality Products come with quality containers! Knowing how your CBD Wellness Products should be best stored is important because this will ensure you are getting the best results when taking it. If you spend lot of money…why should not it come in plastic? Properly store CBD Wellness Products will preserve the quality and potency of your favorite healing products for months. Improperly stored CBD Wellness Products, from flower, edible, cream to oil, lotion and more can quickly dry out, losing potency and flavor – or worse, mold and contamination can grow on your products, rendering it dangerous to consume.

CBD Wellness Products must come in adequate packaging. How your CBD Wellness Products are packaged and stored matters almost as much as how they are sourced, extracted and formulated. The moment a hemp leaf is picked, it begins to die. As it oxygenates, valuable cannabinoids dissipate into the atmosphere. CBD product manufacturers go to great lengths to preserve these natural elements, but they all succumb to the inevitable.

Because quality matter! Not only in the content of the product itself but also in storage material. And, anything that come in plastic is not environmentally friendly. Not only are the harmful effects of global warming increasingly clear, conventional plastics linger in the environment and can even enter the food chain to detrimental effect on human and animal health. In one especially shocking recent example, researchers from the University of Tasmania and the UK’s Royal Society for the Protection of Birds found 38 million pieces of plastic waste on Henderson Island, an uninhabited coral island in the South Pacific.

Glass or Plastic Container?  Packaging is important for nearly every product. When it comes to CBD products, however, it is even more critical. CBD and the other constituents of hemp (such as terpenes) are extremely fragile compounds. Hence, they need to be packaged and stored in a way that preserves their purity and potency for as long as possible.

You spend lot of money to buy your CBD Wellness Products, it doesn’t make sense for you to  pay for expensive products if they do not come with proper storage material. Therefore, it is very important for you to know which one to buy or even to invest in as vendor to care white or private label. Properly storing and caring for your cannabinoid products is important for maintaining their potency and keeping them fresh. The keys to properly storing cannabinoids isn’t complex, but you do need to protect your products from exposure to elements like humidity, heat, extreme cold, and light.

Cannabinoid products have vastly different shelf lives, depending on the type of product and storing conditions. Whether you’re caring for cannabis flower, a tincture, salve, concentrates, edibles or CBD oil, cannabinoids will eventually degrade when exposed to certain elements. Cannabis can last months when stored the right way, and properly cared for tinctures and cannabis oil can last years with little to no degradation if they’re left in an ideal environment.

In general,  all topical and sublingual “CBD Wellness Products” should always be stored in glass or dark tin containers to preserve it quality and potency.  Best to store them in medical-graded glass containers such as  amber, green or blue  cobalt to prevent product degeneration, protect the product against light, heat, and air exposure, because they all play a part in the breakdown of natural cannabinoids like CBD and other fragile ingredients.

CBD Wellness Product in these two categories at least, should never be packed/stored in any plastic related containers. Simply;  because plastic container is not environmentally friendly, and most CBD Wellness Products are not protected in plastic. In opposite, CBD Wellness Products in plastic because high potency formula products will eat through plastic, cause toxic leak and contamination.

Here are more reasons why we use glass:

• All of our topical and sublingual CBD WELLNESS PRODUCTS come in airtight medical or cosmetic graded glass (or tin) containers. We do this for a number of reasons. These containers are completely airtight, even after they have been opened.
• First of all, the airtight nature of the containers helps protect the products once they’ve been opened. Air exposure, much like light and heat, can damage CBD, terpenes, and other hemp constituents. Make sure you close the lid on each of our products securely after every use to keep them at optimal quality.
  
• Secondly, we use glass packaging because it is perfectly suited to topical and sublingual CBD Wellness Products. Poor-quality plastic containers can leak toxic chemicals into liquids and foods. Glass, on the other hand, is nonporous and impermeable; glass packaging has an almost 0% chance of chemically interacting with its contents. That’s why we packed all our products in glass containers – to ensure their quality and high potency, prolong product shelf life, both at our stores and in your home, and protect your health for any toxic and unwanted contamination.
• Third, one of the primary benefits of a glass bottle is that it provides excellent UV protection. UV rays can cause photooxidation, which alters the components that make up certain products. Dark glass such as amber or cobalt helps to keep out deteriorating sunlight. To elongate the life of your CBD products, aim for products in glass containers over plastic. Glass is impermeable. Therefore, it won’t hold onto moisture. While that’s a plus, glass is also transparent. Getting CBD Wellness Products in amber or cobalt containers is ideal because UV rays can’t penetrate through. Unlike many other clear glass, amber or cobalt glass also protects products from blue light. While there are both positives and negative aspects to blue light, the main concern with any type of light exposure is the type of photochemical reaction that may occur. By choosing amber bottles as opposed to any other color, you can protect your products both from UV light and blue light.
• Fourth, in many instances, products stored in amber glass bottles have greater longevity than those stored in clear containers. From ensuring that CBD WELLNESS PRODUCTS especially topical and sublingual do not lose their potency; amber or cobalt glass does a great job of extending the life of the products they store.

• Finally, we use glass over other popular packaging materials (like plastic) because it is more environmentally friendly. Glass is 100% recyclable and up to 80% of recovered glass is reused to make other glass products. In fact, glass can be recycled and back on the shelves in as few as 30 days.

To prolong and preserve the quality of CBD Wellness Products,  it is best to store CBD Wellness Products below 70 degrees Fahrenheit. This means that you can generally store your CBD oil at room temperature between 70-75 degrees Fahrenheit.

The best way to store your CBD oil is in an upright position in a spot with a stable temperature away from extreme light, heat, or moisture. A dry pantry is a perfect place for storing your CBD oil.

Another option is of course to store your CBD oil in your refrigerator. If you decide to store your CBD Wellness Products in refrigerator, be aware that the content of your CBD Wellness Products may change. While this is not required, many people like to do this because they believe it will ensure a longer shelf life for their CBD oil.

You may notice that one drawback of storing CBD oil in your refrigerator is that if the CBD oil gets too cold, it may thicken to the point where you need to heat it a little before use. No problem — you can just run the bottle carefully under some hot water.

If you properly store your CBD oil, you should find that it lasts for about one year. Many people who use CBD regularly will have nothing to worry about since they take CBD oil often enough that they are replacing it with a fresh bottle on a regular basis.

When you are deciding how to store your CBD oil, be aware of the carrier liquid your CBD oil is in. All CBD and hemp extracts come in a carrier liquid within which the concentrated cannabinoid extract is diluted.

Common carrier liquids are coconut oil, MCT oil, olive oil, and hemp seed oil. So all you need to do is store your CBD oil in the same way as you would store your bottle of olive oil or coconut oil.

What Is The Difference Between Full Spectrum, Broad Spectrum, and Isolate CBD Oil?

Understanding the difference between the three major types of CBD products (full spectrum vs broad spectrum vs isolate CBD oil) is one of the most important first steps on your CBD journey. Once you understand the difference between them, you’ll be better equipped to make an educated decision on which CBD oil product to buy for your needs.

The three most popular types of CBD oil used today are: Full Spectrum, Broad Spectrum and Isolate. You may also come across products labeled as “Whole Plant” or “Pure CBD.” This article will explain the differences and similarities among these.

Full Spectrum

Full spectrum (or “whole plant”) products contain CBD as well as terpenes and other cannabinoids such as CBG, CBN and trace amounts of THC. Usually these will be in ratios that were naturally-occurring and extracted from the plant and specific strain. Terpenes and cannabinoids are occasionally added back into products as an isolated form to raise the potency of the product.

Full spectrum products are by far the most popular. With full spectrum CBD oil products, you have the advantage of something called the “entourage effect.” This is where all the cannabinoids and terpenes are working together in synergy, something that broad spectrum and isolate products will lack.

Those subject to drug testing should be cautious when it comes to full spectrum products. The THC found in full spectrum hemp oil products is minimal (less than 0.3%), but can still trigger a positive drug test.

Broad Spectrum

Broad spectrum products contain an array of cannabinoids and terpenes but zero THC based on the manufacturer’s lab testing. Third party lab reports that are readily available from reputable companies can tell you which cannabinoids and terpenes are in the product and at what levels.

These products have often gone through additional processing to try to isolate and remove as much THC as possible while still maintaining the other cannabinoids and terpenes. In other cases, they are isolate-based with additional cannabinoids and terpenes added in.

Isolate

Isolates are typically the CBD oil product of choice for those who get drug tested or are sensitive to other cannabinoids such as THC. Products labeled as isolates will generally be highlighted as being 99+% “pure CBD.” Usually, these products will have nothing but CBD in them because the CBD has literally been isolated from everything else. You can find pre-made isolate oils that typically consist of a carrier oil, such as MCT oil, infused with the crystalline isolate powder. You can also find the “raw” CBD crystalline powder or slabs (a form of concentrate) on its own.

Which is Better – Full Spectrum, Broad Spectrum or Isolate?

While there is much debate on which form is better, this 2015 study leans in favor of full spectrum CBD oil products. There are many that believe that other cannabinoids, THC especially, are necessary to take full advantage of what cannabis has to offer. Ultimately, however, we are all different and it comes down to the individual user and their needs. If drug testing is a concern, you’re encouraged to seek out to do more researches on this topic before taking any CBD related products.

For centuries, people have used the plants that grew around them to treat wounds and help speed healing. Across the world, traditional cures from plants and herbs have been used by herbalists and apothecaries for their medical healing properties throughout the centuries.

Besides adding herbs into our cooking, one of the best ways to receive the benefits of herbs as well as alleviate dry skin is through the creation of a healing salve, healing body butter or healing liniment with essential oil fusions to treat, pain, muscle soreness, bruises, wounds, rashes, other skin irritations and other mental and emotional distress conditions.

There are many powerful, effective natural salves, body butters and liniments that actually work to heal the underlying root cause of our illness and physical discomforts. Throughout the centuries before conventional medication existed, holistic natural salves, body butters and liniments fused with essential oils been used for inflammation and pain and helped people with pain managements and other physical & emotional challenges.

Healing from acute, chronic pain arising from physical, mental or emotional distresses, is safer than taking drugs. Natural supplements such as salves, body butter and liniment for example are not the same as chemically manufactured medicines since they are made of natural & organic ingredients. Unless there is an allergic reaction, natural remedies are safe. Compared to the use of natural remedies (salves, body butter and liniment) medication contains considerable risks that are un and surgical procedures; it is absolutely a safer choice. Even, a small scar resulting from surgery can leave one with long term unwanted negative side effects. Prescription medication and over-the-counter drugs are toxic and have negative effects on the liver, kidney and digestive tract.

Are salves, body butters and liniments should be a better choice and first choice for anyone suffering from pain? The answer is simply, yes! Unlike natural remedies, drugs for inflammation and pain, are created in a lab and our bodies are not equipped to digest and process them. Drugs are incredibly powerful which gives them the ability to offer fast relief of symptoms. Medication is effective for short-term use, but it is harmful over time and begins to cause new damage and side effects and a trail of toxic residue in our body systems.

Natural remedies, on the other hand, are made from natural ingredients includes leaves of twigs, berries, barks, roots, vines, vitamins and minerals. They are natural substances that can’t be regulated by the FDA because they are technically foodstuffs and can be process bio-naturally by the body. Healing salves, body butters and liniment promote healing. They are powerful natural remedies for healing, eliminating inflammation and chronic pain with no residue or long-term negative effects.

For centuries, people have used the plants that grew around them to treat wounds and help speed healing. If you experience nerve pain, then you may know how debilitating this pain can be. From a stabbing pain that may hit you in the middle of the night to uncontrolled nerve pain that is strong and persistent; you would go to any lengths possible to find a way to help alleviate or control this pain.

If you have already tried prescribed painkillers, supplements, and other medicinal ways including steroid & Botox shots and more to help with nerve pain but find they only provide temporary relief and are met with more side effects than you expected, then it might be time to consider a more natural way to help nerve pain.

When we talk about a more natural approach, we are talking about ways to help reduce the pain that does not involve medicinal measures and can use natural remedies such as application of healing essential oils, body butters, liniments and salves can be an effective treatment for chronic pain conditions like strains, sprains, bruises, rheumatoid arthritis, office syndromes, high athletic performances t or from daily strenuous activities.

Healing oils make from herbal plants with medical properties are uses to make salves for nerve pain and nerve damage due to their healing properties as following:

ANTI-NEURALGIC PROPERTIEs, which help to constrict the blood vessels surrounding the nerve, which ultimately helps relieve nerve pressure. Herbal healing plants such as chamomile, marjoram, lavender and helichyrusm oil are remarkable topical healing agent with skin healing, and antineuralgic

ANTI-SPASMODIC TENDENCIES, which stop the spasming of muscles. They halt the impulses and lessen muscle spasming. Examples of such oils include marjoram, basil and juniper-berry.

SEDATIVE – Some essential oils such as lavender and clary sage have natural sedative properties, which help to induce calmness and promote sleep.

STIMULATORY – stimulatory effects in essential oils such as geranium, help in the body. Nervine – Natural nerves compounds found Some essential oils like helichyrusm, have ylang ylang and rosemary properties.

ANTI-VIRAL- ANTIFUNGAL PROPERTIES Some plants such as coconut, calendula, cinnamomum zeylanicum, cloves, melissa officinalis have strong anti-viral and anti-fungal properties.

ANTI-BACTERIAL- Some essential oils such as cinnamomum zeylanicum, cloves, echinacea augustifolia, garlic, mentha piperita, tea tree and thymus strong antibacterial agent as well as a strong antiseptic and antioxidant.

ANALGESIC – The analgesic properties of essential oils give them the ability to achieve analgesia, which means relief from pain. Examples include oil and helichrysum essential oils.

ANTI-INFLAMMATORY – Anti-inflammatory compounds in essential oils. Examples include blue tansy, yarrow and sandalwood essential oils.

ADAPTOGENIC – Adaptogenic essential oils like geranium, when applied topically results in the stabilization and physiological processes. They also reduce stress within cells. Some essential oils like helichyrusm, have ylang ylang and rosemary properties.

ADAPTOGENIC – Adaptogenic essential oils like geranium, when applied topically results in the stabilization and balancing of physiological processes. They also reduce stress within cells. Some essential oils like helichyrusm, have ylang ylang and rosemary properties.

Click here (https://www.ncbi.nlm.nih.gov/pubmed/22625422) and here (https://www.ncbi.nlm.nih.gov/pubmed/18728714) to find evidence of a test, analysis, research, or study describing the benefits, performance or efficacy of CBD Oil based on the expertise of relevant professionals.

Related studies can be found by searching “CBD” at  PubMed:

Below, is an extensive list of scientific publications indicating that CBD may be used as therapeutic treatment for over 50 medical conditions. So if you’re researching into possibly using CBD for a condition you have, and are looking to learn about CBD benefits, read more about the benefits here.

ACNE

• Cannabidiol as a Treatment for Acne?
• Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
• The endocannabinoid system of the skin in health and disease: Novel perspectives and therapeutic opportunities
• Endocannabinoids enhance lipid synthesis and apoptosis of human sebocytes via cannabinoid receptor-2-mediated signaling
• Endocannabinoid signaling and epidermal differentiation

ADD / ADHD

• Searching for a Neurobiological Basis for Self-Medication Theory in ADHD Comorbid With Substance Use Disorders
• Cannabidiol and clozapine reverse MK-801-induced deficits in social interaction and hyperactivity in Sprague-Dawley rats
• Subtypes of Attention Deficit — Hyperactivity Disorder (ADHD) and cannabis use
• Childhood and current ADHD symptom dimensions are associated with more severe cannabis outcomes in college students
• Oral delta 9-tetrahydrocannabinol improved refractory Gilles de la Tourette syndrome in an adolescent by increasing intracortical inhibition: A case report
• Fitness to drive in spite (because) of THC

ADDICTION

• Cannabidiol reduces cigarette consumption in tobacco smokers
• Inhibition of monoacylglycerol lipase enzyme reduces nicotine withdrawal
• Cannabidiol inhibits the reward-facilitating effect of morphine
• Cannabidiol, a nonpsychotropic component of cannabis, inhibits cue-induced heroin seeking and normalizes discrete mesolimbic neuronal disturbances
• Differential effect of cannabinol and cannabidiol on THC-induced responses during abstinence in morphine-dependent rats
• Impact of Cannabis Use during Stabilization on Methadone Maintenance Treatment
• Medical cannabis laws and opioid analgesic overdose mortality in the United States, 1999-2010
• Dysregulation of cannabinoid CB1 receptor and associated signaling networks in brains of cocaine addicts and cocaine-treated rodents
• Comparison of cannabidiol, antioxidants, and diuretics in reversing binge ethanol-induced neurotoxicity
• Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder
• Cannabidiol for the treatment of cannabis withdrawal syndrome
• Cannabis use disorders are comparatively prevalent among nonwhite racial/ethnic groups and adolescents: a nationalstudy

ALS

• Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials
• Medical Cannabis Helps ALS Patient Outlive her Own Doctor

ALZHEIMER’S

• The therapeutic potential of the endocannabinoid system for Alzheimer’s disease
• Endocannabinoid signalling in Alzheimer’s disease
• A molecular link between the active component of marijuana and Alzheimer’s disease pathology
• Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
• The Potential Therapeutic Effects of THC on Alzheimer’s Disease
• The Role of Endocannabinoid Signaling in the Molecular Mechanisms of Neurodegeneration in Alzheimer’s Disease
• Cannabinoids for the treatment of dementia
• Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression
• Cannabidiol: A promising drug for neurodegenerative disorders?
• Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer’s disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition
• The role of the endocannabinoid system in Alzheimer’s disease: facts and hypotheses
• The role of phytochemicals in the treatment and prevention of dementia
• Cannabinoids for the treatment of dementia
• Cannabidiol Promotes Amyloid Precursor Protein Ubiquitination and Reduction of Beta Amyloid Expression in SHSY5YAPP+ Cells Through PPARγ Involvement
• Cannabinoids for treatment of Alzheimer’s disease: moving toward the clinic
• Can Marijuana Prevent Alzheimer’s?

ANOREXIA

• Leptin, ghrelin, and endocannabinoids: Potential therapeutic targets in anorexia nervosa
• The role of the endocannabinoid system in eating disorders: Neurochemical and behavioural preclinical evidence
• Cancer cachexia and cannabinoids

ANXIETY

• Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug
• Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa
• Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients
• Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder
• Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation
• Effects of cannabidiol (CBD) on regional cerebral blood flow
• The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
• Plant-based medicines for anxiety disorders, part 2: A review of clinical studies with supporting preclinical evidence

ATHEROSCLEROSIS

• The role of the endocannabinoid system in atherosclerosis
• Cannabinoid receptors in atherosclerosis
• The potential use of cannabidiol in the therapy of metabolic syndrome

ARTHRITIS

• Preliminary assessment of the efficacy, tolerability and safety of a cannabis-based medicine (Sativex) in the treatment of pain caused by rheumatoid arthritis
• The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
• Involvementof theendocannabinoidsysteminosteoarthritispain
• The abnormal cannabidiol analogue O-1602 reduces nociception in a rat model of acute arthritis via the putative cannabinoid receptor GPR55

ASTHMA

• The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke
• Allergen challenge increases anandamide in bronchoalveolar fluid of patients with allergic asthma
• Activation of cannabinoid receptors prevents antigen-induced asthma-like reaction in guinea pigs
• Endogenous cannabinoid receptor agonists inhibit neurogenic inflammations in guinea pig airways
• Bronchodilator effect of delta1-tetrahydrocannabinol

AUTISM

• Mutations found in individuals with autism interfere with endocannabinoid signaling in the brain
• Cannabinoid receptor type 2, but not type 1, is up-regulated in peripheral blood mononuclear cells of children affected by autistic disorders
• A novel approach to the symptomatic treatment of autism
• Consequences of cannabinoid and monoaminergic system disruption in a mouse model of autism spectrum disorders
• Targeting the endocannabinoid system in the treatment of fragile X syndrome

BIPOLAR AFFECTIVE DISORDER

• Cannabinoids in bipolar affective disorder: A review and discussion of their therapeutic potential
• Cannabidiol was ineffective for manic episode of bipolar affective disorder

CANCER

General

• Cannabidiol as potential anticancer drug
• Cannabidiol inhibits angiogenesis by multiple mechanisms
• The inhibitory effects of cannabidiol on systemic malignant tumors
• Cannabidiol inhibits cancer cell invasion via upregulation of tissue inhibitor of matrix metalloproteinases-1

Lung

• Cannabidiol inhibits lung cancer cell invasion and metastasis via intercellular adhesion molecule-1C
• COX-2 and PPAR-γ confer cannabidiol-induced apoptosis of human lung cancer cells
• Decrease of plasminogen activator inhibitor-1 may contribute to the anti-invasive action of cannabidiol on human lung cancer cells
• Media ignored expert’s shocking findings that marijuana helps prevent lung cancer

Prostate / Colon

• Towards the use of non-psychoactive cannabinoids for prostate cancer
• In Vitro Anticancer Activity of Plant-Derived Cannabidiol on Prostate Cancer Cell Lines
• Induction of apoptosis by cannabinoids in prostate and colon cancer cells is phosphatase dependent
• Chemopreventive effect of the non-psychotropic phytocannabinoid cannabidiol on experimental colon cancer
• Inhibition of colon carcinogenesis by a standardizedCannabis sativaextract with high content of cannabidiol

Breast

• Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
• Cannabidiol induces programmed cell death in breast cancer cells by coordinating the cross-talk between apoptosis and autophagy
• Pathways mediating the effects of cannabidiol on the reduction of breast cancer cell proliferation, invasion, and metastasis
• Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
• Cannabidiolic acid, a major cannabinoid in fiber-type cannabis, is an inhibitor of MDA-MB-231 breast cancer cell migration

Glioblastoma / Brain

• Cannabidiol enhances the inhibitory effects of delta9-tetrahydrocannabinol on human glioblastoma cell proliferation and survival
• Antitumor effects of cannabidiol, a nonpsychoactive cannabinoid, on human glioma cell lines(PubMed)
• Systematic review of the literature on clinical and experimental trials on the antitumor effects of cannabinoids in gliomas
• Cannabidiol inhibits human glioma cell migration through a cannabinoid receptor-independent mechanism
• Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target
• Triggering of the TRPV2 channel by cannabidiol sensitizes glioblastoma cells to cytotoxic chemotherapeutic agents
• Cannabidiol, a non-psychoactive cannabinoid compound, inhibits proliferation and invasion in U87-MG and T98G glioma cells through a multitarget effect
• Local delivery of cannabinoid-loaded microparticles inhibits tumor growth in a murine xenograft model of glioblastoma multiforme

Leukemia

• Cannabidiol-induced apoptosis in human leukemia cells: A novel role of cannabidiol in the regulation of p22phox and Nox4 expression
• Cannabidiol-Induced Apoptosis in Human Leukemia Cells

Skin

• Anticancer activity of anandamide in human cutaneous melanoma cells

Kaposi Sarcoma

• Cannabidiol inhibits growth and induces programmed cell death in kaposi sarcoma-associated herpes virus-infected endothelium(PubMed)

Endocrine

• Endocannabinoids in endocrine and related tumours
• A comparative study on cannabidiol-induced apoptosis in murine thymocytes and EL-4 thymoma cells

Bladder

• TRPV2 activation induces apoptotic cell death in human T24 bladder cancer cells: a potential therapeutic target for bladder cancer

Pain

• Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
• Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial
• Marijuana extract helps prevent chemo pain

CROHN’S & COLITIS

• Cannabidiol in inflammatory bowel diseases: a brief overview
• Cannabis finds its way into treatment of Crohn’s disease
• Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
• Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
• The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis
• Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice
• Cannabinoids and the gut: New developments and emerging concepts
• Endocannabinoids and the gastrointestinal tract
• Cannabinoids and gastrointestinal motility: Animal and human studies
• Hergenrather presents study of Crohn’s patients as a template for clinical research on Cannabis

DEMENTIA

Study: Plant-Derived THC/CBD Extracts Reduce Dementia Symptoms

DEPRESSION

• Endocannabinoid system dysfunction in mood and related disorders
• Antidepressant-Like and Anxiolytic-Like Effects of Cannabidiol: A Chemical Compound of Cannabis Sativa
• The endocannabinoid system and the treatment of mood and anxiety disorders
• Endocannabinoid signaling in the etiology and treatment of major depressive illness
• Antidepressant-like effects of cannabidiol in mice: Possible involvement of 5-HT1A receptors
• Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants
• Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa
• Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress
• Serum contents of endocannabinoids are correlated with blood pressure in depressed women
• The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants
• Antidepressants and Changes in Concentration of Endocannabinoids and N-Acylethanolamines in Rat Brain Structures

ENDOCRINE DISORDERS

• Endocannabinoid system participates in neuroendocrine control of homeostasis
• The emerging role of the endocannabinoid system in endocrine regulation and energy balance
• Endocannabinoids in endocrine and related tumours
• Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas
• The role of the endocannabinoid system in the neuroendocrine regulation of energy balance

EPILEPSY & SEIZURES

• CBD for children with Dravet’s and intractable seizures
• Report of a parent survey of cannabidiol-enriched cannabis use in pediatric treatment-resistant epilepsy
• Medicinal marijuana stops seizures, brings hope to a little girl
• Cannabinoids for epilepsy
• Cannabis, cannabidiol, and epilepsy – From receptors to clinical response
• The non-psychotropic plant cannabinoids, cannabidivarin (CBDV) and cannabidiol (CBD), activate and desensitize transient receptor potential vanilloid 1 (TRPV1) channels in vitro: potential for the treatment of neuronal hyperexcitability
• Chronic administration of cannabidiol to healthy volunteers and epileptic patients
• Endocannabinoid system protects against cryptogenic seizures
• Seizing an opportunity for the endocannabinoid system
• Cannabidiol: promise and pitfalls
• Cannabidiol:Pharmacologyandpotentialtherapeuticroleinepilepsyandotherneuropsychiatricdisorders
• Report of a parent survey of cannabidiol-enriched cannabis use in pediatrictreatment-resistant epilepsy
• From theEditors:Cannabidiolandmedicalmarijuanafor thetreatmentofepilepsy
• Cannabidivarin (CBDV) suppressespentylenetetrazole (PTZ)-inducedincreases in epilepsy-related gene expression
• Cannabidiol exerts anti-convulsant effects in animal models of temporal lobe and partial seizures
• Cannabidiol displays antiepileptiform and antiseizure properties in vitro and in vivo
• Hypnotic and antiepileptic effects of cannabidiol
• The cannabinoids as potential antiepileptics
• Cannabidiol–antiepileptic drug comparisons and interactions in experimentally induced seizures in rats

FIBROMYALGIA

• Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
• Cannabis use in patients with fibromyalgia: effect on symptoms relief and health-related quality of life

GLAUCOMA

• Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite
• Effect of sublingual application of cannabinoids onintraocularpressure: A pilot study

HEART DISEASE

• Is the cardiovascular system a therapeutic target for cannabidiol?
• Acute administration of cannabidiol in vivo suppresses ischaemia-induced cardiac arrhythmias and reduces infarct size when given at reperfusion
• Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy
• The Effect ofCannabidiolon Ischemia/Reperfusion-Induced Ventricular Arrhythmias: The Role of Adenosine A1 Receptors
• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
• Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension
• Oleamide: A fatty acid amide signaling molecule in the cardiovascular system?

HUNTINGTON’S DISEASE

• Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease
• Cannabinoids: Novel medicines for the treatment of Huntington’s disease
• Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington’s disease: role of CB(1) and CB(2) receptors
• Controlled clinical trial of cannabidiol in Huntington’s disease
• Prospects for cannabinoid therapies in basal ganglia disorders
• Neuroprotective Properties of Cannabigerol in Huntington’s Disease: Studies in R6/2 Mice and 3-Nitropropionate-lesioned Mice

INFLAMMATION

• Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress
• The endocannabinoid system: an emerging key player in inflammation
• Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice
• Cannabinoids, endocannabinoids, and related analogs in inflammation
• Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
• Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
• Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation
• Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement
• Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption
• Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
• Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death
• Cannabinoids in clinical practice

IRRITABLE BOWEL SYNDROME

• Cannabidiol in inflammatory bowel diseases: A brief overview
• Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis
• Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
• Cannabinoid actions at TRPV channels: Effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation
• Therapeutic potential of cannabinoid-based drugs
• Beneficial effect of the non-psychotropic plant cannabinoid cannabigerol on experimental inflammatory bowel disease (Biochemical Pharmacology)
• Cannabinoids and the gut: New developments and emerging concepts
• Endocannabinoids and the gastrointestinal tract
• Cannabinoids and gastrointestinal motility: Animal and human studies

KIDNEY DISEASE

• Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death

LIVER DISEASE

• The endocannabinoid system and liver diseases
• Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death
• Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis
• Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats
• Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol
• Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice
• Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation

METABOLIC SYNDROME

• The impact of marijuana use on glucose, insulin, and insulin resistance among US adults
• The potential use of cannabidiol in the therapy of metabolic syndrome
• Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes

MIGRAINES

• Clinical endocannabinoid deficiency (CECD): Can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?
• Effects of anandamide in migraine: data from an animal model
• Cannabinoids and hallucinogens for headache
• The endocannabinoid system and migraine
• Variations in the cannabinoid receptor 1 gene predispose to migraine

MOOD DISORDERS

• Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders
• The endocannabinoid system and the treatment of mood and anxiety disorders
• The endocannabinoid system and psychiatric disorders
• The endocannabinoid system in the regulation of emotions throughout lifespan: A discussion on therapeutic perspectives
• Endocannabinoid system dysfunction in mood and related disorders
• Effects of cannabidiol (CBD) on regional cerebral blood flow

MOTION SICKNESS

• Motion sickness, stress and the endocannabinoid system
• Dexamethasone alleviates motion sickness in rats in part by enhancing the endocannabinoid system

MULTIPLE SCLEROSIS

• Sativex for the management of multiple sclerosis symptoms
• THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis
• Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity
• Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: A role for A2A receptors
• Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: An uncontrolled, open-label, 2-year extension trial
• Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis
• Sativex long-term use: An open-label trial in patients with spasticity due to multiple sclerosis
• A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis
• Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain(
• Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain

NAUSEA

• Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system(PubMed)
• Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT(1A) somatodendritic autoreceptors in the dorsal raphe nucleus
• Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT1A receptor activation
• Interaction between non-psychotropic cannabinoids in marihuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews
• Regulation of nausea and vomiting by cannabinoids
• Cannabidiol, a non-psychoactive component of cannabis and its synthetic dimethylheptyl homolog suppress nausea in an experimental model with rats
• Preliminary efficacy and safety of an oromucosal standardized cannabis extract in chemotherapy-induced nausea and vomiting

NEURODEGENERATION

• Cannabidiol: A promising drug for neurodegenerative disorders?
• Cannabidiol for neurodegenerative disorders: Important new clinical applications for this phytocannabinoid?
• Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder
• Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders
• Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection

NEUROPATHIC PAIN

• Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain
• Sativex: Clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain
• Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine
• Sativex successfully treats neuropathic pain characterised by allodynia: A randomised, double-blind, placebo-controlled clinical trial
• Cannabinoids for neuropathic pain
• Neuropathic orofacial pain: Cannabinoids as a therapeutic avenue
• Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial
• The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain
• Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
• Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT1A receptors without diminishing nervous system function or chemotherapy efficacy
• Antihyperalgesic effect of a Cannabis sativa extract in a rat model of neuropathic pain: Mechanisms involved
• Non-psychoactive cannabinoids modulate the descending pathway of antinociception in anaesthetized rats through several mechanisms of action
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
• Role of the cannabinoid system in pain control and therapeutic implications for the management of acute and chronic pain episodes
• Cannabinoids in the management of difficult to treat pain
• Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain
• Marijuana extract helps prevent chemo pain
• Pot users less likely to take painkillers

OBESITY

• The impact of marijuana use on glucose, insulin, and insulin resistance among US adults
• Cannabinol and cannabidiol exert opposing effects on rat feeding patterns
• Cannabis and Δ9-tetrahydrocannabinol (THC) for weight loss?
• The endocannabinoid system in obesity and type 2 diabetes
• Role of the endocannabinoid system in abdominal obesity and the implications for cardiovascular risk
• Cannabinoids and endocannabinoids in metabolic disorders with focus on diabetes

OCD

• Plasma and brain pharmacokinetic profile of cannabidiol (CBD), cannabidivarine (CBDV), Δ⁹-tetrahydrocannabivarin (THCV) and cannabigerol (CBG) in rats and mice following oral and intraperitoneal administration and CBD action on obsessive-compulsive behaviour(PubMed)

PAIN

• Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis
• Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors
• Patterns of medicinal cannabis use, strain analysis, and substitution effect among patients with migraine, headache, arthritis, and chronic pain in a medicinal cannabis cohort
• Cannabidiol Is a Potential Therapeutic for the Affective-Motivational Dimension of Incision Pain in Rats
• Translational Investigation of the Therapeutic Potential of Cannabidiol (CBD): Toward a New Age

PARKINSON’S DISEASE

• Effects of cannabidiol in the treatment of patients with Parkinson’s disease: An exploratory double-blind trial
• Prospects for cannabinoid therapies in basal ganglia disorders
• Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson’s disease: Importance of antioxidant and cannabinoid receptor-independent properties
• Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson’s disease
• Cannabidiolcanimprovecomplexsleep-relatedbehavioursassociatedwithrapideyemovementsleepbehaviourdisorderinParkinson’sdiseasepatients: acaseseries
• Cannabidiol for the treatment of psychosis in Parkinson’s disease
• Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson’s disease
• Therapeutic potential of cannabinoids in CNS disease

PRION – MCD

• Nonpsychoactive cannabidiol prevents prion accumulation and protects neurons against prion toxicity
• Cannabidiol: A prion therapy for mice?

PTSD

• The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD
• Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the world trade center attacks
• Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear
• Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via CannabinoidReceptors
• Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: Possible involvement of 5HT1A receptors
• Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis
• Mitigation of post-traumatic stress symptoms by Cannabis resin: A review of the clinical and neurobiological evidence
• Cannabinoid modulation of fear extinction brain circuits: A novel target to advance anxiety treatment
• The endocannabinoid system and extinction learning
• A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers
• Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit
• Non-antidepressant long-term treatment in post-traumatic stress disorder
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: Involvement of the endocannabinoid system
• Modulation of Fear Memory by Dietary Polyunsaturated Fatty Acids via Cannabinoid Receptors

RHEUMATISM

• Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

SCHIZOPHRENIA

• Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug
• Cannabidiol as a potential treatment for psychosis
• Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia
• Medical use of cannabis. Cannabidiol: A new light for schizophrenia?
• A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation
• Peripheral endocannabinoid system dysregulation in first-episode psychosis
• Cannabinoids and schizophrenia: Therapeutic prospects
• Antipsychotic-like effects of cannabidiol and rimonabant: Systematic review of animal and human studies
• Cannabidiol monotherapy for treatment-resistant schizophrenia
• Cannabis with high cannabidiol content is associated with fewer psychotic experiences
• Marijuana compound treats schizophrenia with few side effects: Clinical trial
• Clearingthesmoke: what do we know about adolescent cannabis use and schizophrenia?

SICKLE CELL ANEMIA

• Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: Modulation by cannabinoids
• Cannabis use in sickle cell disease: A questionnaire study

SKIN CONDITIONS

• Cannabinoids inhibit human keratinocyte proliferation through a non-CB1/CB2 mechanism and have a potential therapeutic value in the treatment of psoriasis
• Cannabidiol exerts sebostatic and antiinflammatory effects on human sebocytes
• The endocannabinoid system of the skin in health and disease: Novel perspectives and therapeutic opportunities
• Epigenetic control of skin differentiation genes by phytocannabinoids
• Endocannabinoids modulate human epidermal keratinocyte proliferation and survival via the sequential engagement of cannabinoid receptor-1 and transient receptor potential vanilloid-1
• Cannabinoid 1 receptors in keratinocytes modulate proinflammatory chemokine secretion and attenuate contact allergic inflammation
• Attenuation of allergic contact dermatitis through the endocannabinoid system
• Topical cannabinoid agonists. An effective new possibility for treating chronic pruritus

SLEEP DISORDERS

• The nonpsychoactive Cannabis constituent cannabidiol is a wake-inducing agent
• Cannabis, pain, and sleep: Lessons from therapeutic clinical trials of Sativex, a cannabis-based medicine
• Effects of acute systemic administration of cannabidiol on sleep-wake cycle in rats
• Effect of Delta-9-tetrahydrocannabinol and cannabidiol on nocturnal sleep and early-morning behavior in young adults
• Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats
• Endocannabinoid modulation of cortical up-states and NREM sleep
• Intranodose ganglion injections of dronabinol attenuate serotonin-induced apnea in Sprague-Dawley rat

SPINAL CORD INJURY

• Cannabidiol-treated rats exhibited higher motor score after cryogenic spinal cord injury

STRESS

• Endogenous cannabinoid signaling is essential for stress adaptation
• Regulation of endocannabinoid signaling by stress: Implications for stress-related affective disorders
• Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output
• Neuromodulators, stress and plasticity: a role for endocannabinoid signalling
• Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress
• Endocannabinoids and stress
• Stress regulates endocannabinoid-CB1 receptor signaling
• Chronic Stress Impairs α1-Adrenoceptor-Induced Endocannabinoid-Dependent Synaptic Plasticity in the Dorsal Raphe Nucleus
• Endocannabinoid-mediated modulation of stress responses: Physiological and pathophysiological significance
• Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression
• Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory
• The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system
• Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid

STROKE/TBI

• Cannabidiol, a nonpsychoactive Cannabis constituent, protects against myocardial ischemic reperfusion injury
• Cannabidiol prevents infarction via the non-CB1 cannabinoid receptor mechanism
• Cannabidiol prevents cerebral infarction via a serotonergic 5-hydroxytryptamine1A receptor-dependent mechanism(
• Cannabidiol administration after hypoxia-ischemia to newborn rats reduces long-term brain injury and restores neurobehavioral function
• Protective Effects of Cannabidiol Against Hippocampal Cell Death and Cognitive Impairment Induced by Bilateral Common Carotid Artery Occlusion in Mice
• Repeated treatment with cannabidiol but not Delta9-tetrahydrocannabinol has a neuroprotective effect without the development of tolerance

1. What Should Have On Your CBD Labels?

   Labeling CBD products can be an incredibly confusing process with the lack of specific regulations surrounding the product’s booming popularity. Unfortunately, the lack of strict CBD label requirements is leading to mislabeled CBD products and a trend of lawsuits being filed against companies dues to mislabeled CBD packaging or misleading marketing. So you must pay close attention to your product labels to ensure they’re compliant with both federal and state laws.

   Since the Food and Drug Administration (FDA) doesn’t currently allow the sale of CBD ingestible products, it’s important to note the labeling requirements on a state-by-state basis. Some states permit the sale of CBD in foods and dietary supplements but require specific label information and warning requirements. To help you understand where your product fits, the FDA has put together a list of the 26 most common questions about cannabis products and their regulations.

   We’ve put together some important things every CBD seller should include on their CBD product labels. We’ve also included some common mistakes you should avoid.

   At a minimum, you should follow the FDA regulations for cosmetic product labeling for your CBD-infused products below. If you’re selling in a state that allows edible CBD products, then make sure to check state regulations for CBD label requirements.

   • Do not make any false or misleading claims of treating or preventing disease. The FDA has already sent warning letters to companies selling CBD products that have made these false claims.
   • Properly display your label information (See 6 items below) and make sure it’s legible.
   • Do not violate the Poison Prevention Packaging Act of 1970.
   1. Product identity

   This is what your CBD product is or does. It must be included on the Product Display Panel (PDP) of your product. This is not the brand or trade name, but it must be easy to locate and see. It doesn’t have to be on the inner container of a product but putting it in both places is often helpful to consumers.

   2. Net quantity of contents

   You must state the amount of the actual product without any of the packaging or container, as well as the amount of active CBD per serving. This must be measured by volume for liquids or by weight for solids. The net contents must appear within the bottom 30% of the PDP of the outer container and on an informational panel on an inner container.

   3. Name and place of business

   Customers must have a way to contact the manufacturer or distributor. The name and address are required on an informational panel on both the outer and inner packaging of your CBD product. Including a phone number is also a good idea or a QR code where consumers can get more information.

   4. Ingredient declaration

   All CBD products require a full declaration of all ingredients. They must be listed on an informational panel on the outer packaging but isn’t a requirement on inner containers.

   5. Warning or caution statements

   It’s a good idea to include the standard warnings for children and pregnant women as well as any complications for people taking other medications. It’s also a good idea to include a warning that users could fail a drug test if consuming hemp products as well.

   6. Disclosure of material facts

   These are any facts that a reasonable person would deem to be important, significant or essential when buying your CBD product. For instance, if your CBD oil is only good for nighttime use, then that should be disclosed.

   Other things that you should consider including for consumers:

   • Whether your product is full-spectrum, broad-spectrum or isolate
   • Expiration date
   • Manufacturing date
   • Batch codes
   • Product barcode

   Please note:  The suggestions above are just guidelines. You should consult all federal, state and local regulations that pertain to your CBD product before completing your labels. “Note: This article is not intended to be legal advice. Nor is it meant to encapsulate the entirety of CBD labeling restrictions, especially where individual state mandates are concerned. It is meant to present an overview of CBD labeling regulations and their importance. It offers certain considerations that may benefit the designer of a CBD label should she or he hold them in mind.”

    

1. Hempseed oil is often referred to as “hemp oil,” and it’s harvested by cold-pressing hemp seeds. Hemp oil is often unrefined. It’s a clear green oil and can have a nutty flavor.

   It’s different from cannabidiol (CBD) oil, which is an extract of the cannabis plant and utilizes hemp flowers and leaves for its production. Hempseed oil is made from the hemp seed itself and usually doesn’t contain any THC (tetrahydrocannabinol), the psychoactive component, although this seems to be widely disputedTrusted Source. According to 2017 researchTrusted Source, CBD oil may also have very low and insignificant levels of THC.

   Hemp oil has numerous health benefits, including those that improve skin health. It’s so beneficial for skin health thanks to its nourishing vitamins and moisturizing qualities.

   HOW DOES HEMP OIL BENEFIT YOUR SKIN?

   There are a number of skin care benefits that you can get from using hempseed oil, either topically or by consuming it.

   MODERATES OIL PRODUCTION: Hemp oil is perfect for most skin types as it can moisturize without clogging your pores. It can even help to balance out oily skin, hydrating it and regulating the skin’s oil production. Dryness can also cause your skin to overproduce oil, which in turn, can stimulate acne. Hemp oil can prevent dry skin without clogging pores. This helps reduce acne that’s caused by excess oil.

   MOISTURIZES AND SOOTHES INFLAMMATION: One of the omega-6 fatty acids that hemp oil contains is gamma-linolenic acid (GLA), which acts as a powerful anti-inflammatory while simultaneously encouraging skin growth and new cell generation. This can help to calm inflammation and irritation on the skin, including acne and some conditions like psoriasis, while keeping the skin nourished and moisturized.

   TREATS ATOPIC DERMATITIS: Part of what makes hempseed oil so beneficial to the skin is that it’s rich in omega-6 and omega-3 fatty acids. Consuming these nutrients can help to treat skin conditions like atopic dermatitis.One randomized, single-blind crossover study found evidence that dietary hempseed oil reduced the symptoms and appearance of clinical atopic dermatitis after 20 weeks.

   HAS ANTI-AGING PROPERTIES: In addition to moisturizing and soothing the skin, hemp oil has anti-aging properties. Hemp oil can help reduce fine lines and wrinkles as well as prevent signs of aging from developing. The linoleic acid and oleic acids found in hemp oil can’t be produced by the body but can play a crucial role in skin health and anti-aging, so they’re important nutrients to add to the diet.

   WHAT ARE THE SIDE EFFECTS AND RISKS?

   Hempseed oil is safe for most people to use and usually doesn’t contain any CBD or THC or psychoactive properties, although this has been widely disputed. Using it topically, some people may experience mild irritation, so apply it to a small test patch of skin first (whether you’re using pure hemp oil or hemp oil diluted with essential oils).

   Whether applied topically or ingested orally, hempseed oil offers numerous benefits for skin health, and many people can take advantage of those benefits. Hemp oil is considered safe for most people to use, and it can help moisturize the skin from the inside out.

   Consuming hempseed oil may cause some negative side effects in some people:

   • The most common side effect is loosened stools or digestive upset, which can occur as a result of the oily, fatty nature of the oil. To prevent this, start by taking a small amount of hemp oil daily and working your way up.
   • Hemp seeds can interact with blood thinners by potentially inhibiting platelets, so before taking hempseed oil regularly, talk to your doctor to see if it’s right for you.

If you have a toothache, backache, or any other type of pain, your first impulse may be to reach for a pill. Many people rely on medications, but they come with the risk of side effects, drug interactions, and habitual use or addiction.

You may find the relief you need from a variety of natural painkillers instead. Many herbs and spices can treat inflammation and other related conditions. These plant-based options fall under a category of treatment known as alternative medicine, which also includes acupuncture, yoga, Reiki, and other practices. When it comes to pain relief, you may be surprised by what might help you feel better.

Willow bark

People have been using willow bark to ease inflammation, the cause of most aches and pains, for centuries. The bark of the white willow contains the chemical salicin, which is similar to the main ingredient in aspirin (Bayer). Originally, people chewed the bark itself to relieve pain and fevers. Now willow bark is sold as a dried herb that you can brew like tea. It also comes as a liquid supplement or in capsule form. You can use willow bark to help relieve discomfort from headaches, low back pain, osteoarthritis (OA), and many other conditions.

However, willow bark comes with its own risk of side effects. It can cause stomach upset, may slow down your kidneys, and can prolong bleeding time, just like aspirin. It should only be used by adults. Similar to how aspirin taken in large quantities can be harmful for children, willow bark could be poisonous to children.

If you’re sensitive to aspirin, or if you’re taking any over-the-counter (OTC) anti-inflammatory drugs (like aspirin, ibuprofen, or naproxen), you should avoid willow bark. You should also avoid taking it if you’re taking warfarin (Coumadin) or other anticoagulant treatments, as salicin could increase the risk of bleeding. Talk to your doctor before taking willow bark if you’re taking other anti-inflammatory or pain medications.

Turmeric

Turmeric is the spice that gives curry its yellow color and unique flavor. It contains the compound curcumin, an antioxidant that helps protect the body from free radical molecules that can damage cells and tissue. Turmeric can also be used for the treatment of many conditions, including:

• indigestion
• ulcers
• stomach upset
• psoriasis
• cancer

Some people with OA also turn to turmeric as a natural pain reliever because it helps relieve inflammation.

Cloves

Whole cloves are often used to spice up meat and rice dishes. Ground cloves are used in pies and many other foods. As a medicine, cloves can be found in capsule or powder form. Clove oil is also available.

Like other herbal supplements, you can use cloves to treat a wide range of conditions. Cloves may help ease nausea and treat colds. They may also help relieve the pain associated with headaches, arthritic inflammation, and toothaches. Cloves can also be used as part of a topical pain reliever.

One study suggested that cloves could be used to treat fungal infections, but further research is needed.

The active ingredient in cloves is eugenol, a natural pain reliever that’s also used in some OTC pain rubs. Rubbing a tiny amount of clove oil on your gums may temporarily ease toothache pain until you can get to a dentist. But too much undiluted clove oil may actually hurt your gums, so discuss this approach with your dentist before trying it at home.

People with bleeding disorders or who are taking blood-thinning medication should be careful when consuming clove products. Clove oil can increase the risk of abnormal bleeding.

Acupuncture

This ancient Chinese medical practice seeks to relieve pain by balancing the body’s natural energy pathways. The flow of energy is known as qi (pronounced CHEE).

For this practice, acupuncturists place tiny, thin needles into your skin. The location of the insertion is related to the source of the pain. Based on the qi, a needle may be inserted far from the part of the body experiencing pain. Acupuncture may relieve pain by causing the body to release serotonin, a “feel-good” chemical that eases pain.

A 2012 study found that acupuncture helped relieve pain associated with OA, migraines, and various locations of chronic pain.

Heat and ice

Among the most common home pain remedies is applying heat and ice directly to sites of pain. While this treatment may seem obvious, not everyone’s clear on exactly when to use ice versus heat.

Applying an ice pack to reduce swelling and inflammation shortly after you experience a strained muscle, tendon, or ligament may bring relief. Interestingly, once the inflammation has disappeared, heat may help reduce the stiffness that comes with sprains and strains.

A cold pack used briefly on the head may also help take away the pain of a headache.

If your painful problem is arthritis, moist heat applied to the affected joint will help more than ice. Moist heat packs can be warmed in the microwave and used many times, making them effective and easy to use.

If you get injured, talk with your doctor or pharmacist about how to best use heat or ice to help ease the pain.

Be careful when managing pain

The natural painkillers described above may only be effective for specific causes of pain. It’s possible that not all of the suggestions on this list will work for you. However, these natural alternatives to

Benefits of Magnesium Oil

Do you experience insomnia, constipation, leg cramps, PMS Symptoms or general stress and anxiety more than you’d like? If so, magnesium may be of some assistance to you.

Magnesium is an essential nutrient, but in this high-stress, fast-paced world we all seem to be lacking sufficient amounts of it. Did you know that other than getting magnesium naturally from food sources (such as spinach, almonds, pumpkin seeds, avocado, or yogurt) or taking it internally in your favorite multivitamin or supplement, it can be applied topically for additional health benefits?

Why Are We Lacking Magnesium?

Magnesium deficiency is widespread because many of us have lifestyle factors that actively deplete our magnesium levels such as lack of sleep, excess stress, or alcohol/caffeine/sugar consumption. On top of that, many natural sources of magnesium are becoming depleted. Our soil contains less magnesium due to over-farming and high pesticide use. Water filtration systems also remove much of the naturally occurring magnesium in water.

The ocean is still a wonderful source of magnesium and trace minerals, but for those of us who don’t have daily access to a beach, transdermal magnesium oil can be the easiest and most effective way to increase magnesium levels.

Magnesium Is Involved in Hundreds of Biochemical Reactions in Your Body

Magnesium is a mineral found in the earth, sea, plants, animals and humans. About 60% of the magnesium in your body is found in bone, while the rest is in muscles, soft tissues and fluids, including blood (1Trusted Source).

In fact, every cell in your body contains it and needs it to function.

One of magnesium’s main roles is acting as a cofactor or “helper molecule” in the biochemical reactions continuously performed by enzymes.

In fact, it’s involved in more than 600 reactions in your body, including (2Trusted Source):

• Energy creation:Helps convert food into energy.
• Protein formation:Helps create new proteins from amino acids.
• Gene maintenance:Helps create and repair DNA and RNA.
• Muscle movements:Is part of the contraction and relaxation of muscles.
• Nervous system regulation:Helps regulate neurotransmitters, which send messages throughout your brain and nervous system.

 Magnesium Oil Benefits

1. Improved Magnesium Levels

Obviously, the goal of magnesium oil use is to increase the body’s magnesium levels. A 2010 British study conducted by the Herbal Research Centre showed a 25%+ increase in cellular magnesium levels in participants who used transdermal magnesium therapy for 12 weeks. Transdermal magnesium therapy includes magnesium soaks and magnesium spray. I personally consider this a basic form of nutritional insurance since it is so difficult to get magnesium from food and water.

2. Smoother Skin

I also really like using magnesium oil for healthier skin along with dry brushing. I dry brush in the mornings and use magnesium spray at night and this helps my skin stay smooth and breakout free. (People with sensitive skin should start with diluted magnesium oil and work up as their skin allows).

3. Less Muscle Soreness

Many athletes swear by magnesium for post-workout recovery. Even those of us who aren’t high-level athletes can benefit from using magnesium after workouts. Studies indicate that magnesium spray may help reduce muscle cramping and replenish magnesium levels lost through sweat.

4. Fewer Headaches and Migraines

There is a lot of research about magnesium’s importance for those who suffer from headaches or migraines. It isn’t an acute treatment for symptom relief, but the studies indicate that those who have optimal levels of cellular magnesium have fewer instances of headaches and migraines.

5. Balanced Blood Sugar

There is also quite a bit of research regarding magnesium and balanced blood sugar levels. This may be for several reasons. As mentioned above, excess sugar consumption depletes magnesium levels in the body. Having unbalanced blood sugar and insulin levels may deplete magnesium. This, in turn, makes it more difficult to properly balance blood sugar and insulin. Magnesium is not a treatment for diabetes or blood sugar imbalance but studies show that magnesium may be an important part of a holistic approach to blood sugar management.

6. 6. Lower Risk of Blood Pressure and Hypertension

Hospitals routinely use IV magnesium as an acute treatment for high blood pressure. Most of us aren’t giving ourselves IV magnesium at home though and until recently there hasn’t been much well-documented information about supplemental magnesium and blood pressure. A 2012 meta-analysis of available literature in the European Journal of Clinical Nutrition found: “Magnesium supplementation appears to achieve a small but clinically significant reduction in BP, an effect worthy of future prospective large randomized trials using solid methodology.”

Research shows magnesium can ease stress, anxiety, muscle/joint pain, and headaches, and aid in promoting restful sleep. This powerful magnesium oil spray absorbs quickly into your body for maximum relief. Made with ancient magnesium, this highly portable and fast-acting spray is a must-have post workout or whenever aches and pain strike.  Our spray is more effective than taking pills orally. Your skin will easily absorb it and deliver much-needed magnesium to your bloodstream and cells for fast-acting relief. Ultra-absorbent, odorless, and non-greasy, simply spray this magnesium chloride oil on your skin. 

People use our magnesium oil spray to relieve restless night, muscle cramps & DOMS, joint pain, knee and elbow pain, headaches, ease menstrual cramp, promotes collagen and energy.

MAGNESIUM DEFICIENCY IS REAL, AND IT’S PROBABLY AFFECTING YOU

According to the World Health Organization (WHO) 80% of Americans suffer from low magnesium levels. Magnesium is a vital mineral that when deficient, can have a variety of negative effects on our bodies. Symptoms of Mg deficiency may include:

• Agitation and anxiety
• Restless leg syndrome (RLS)
• Sleep disorders
• Abnormal heart rhythms
• Low blood pressure
• Muscle spasm and weakness
• Hyperventilation
• Insomnia

MAGNESIUM: NATURES #1 MIRACLE MINERAL.

Magnesium is required in large amounts for virtually every living cell and every biochemical process, but thanks to our modern diets and lifestyle, we just aren’t getting it. In fact, recent studies show that over 2/3rds of Americans are magnesium deficient, with some studies placing that number as high as 80%.

WHY ARE WE DEFICIENT?

Over time as modern industrial agriculture has grown, our soils have seen a corresponding decline in magnesium levels. The result is that there is less magnesium available in the foods we eat today compared to just over 50 years ago. This problem is compounded by the daily consumption of caffeine and modern medications, both of which leach the magnesium mineral from our systems faster than we can replace it. Magnesium is also a water-soluble mineral, meaning that every time water leaves our body, our magnesium levels are suffering.

WHY IS MAGNESIUM OIL THE BEST WAY?

The best way to boost your magnesium levels is to use our Pure Magnesium Oil, which is a magnesium chloride solution – the most bioavailable inorganic magnesium known. It has the ability to be absorbed rapidly via the skin directly to your cells. Topical magnesium utilizes the bloodstream to circulate throughout the entire body and intelligently deliver magnesium to the specific sites where your body needs it most. When you choose to supplement with topical magnesium oil, you are choosing to give your body exactly what it needs, in the right proportions, the way that nature intended.

WHY DOES MY SKIN FEEL ITCHY?

“FINALLY, A SIGN THAT YOU’RE ONTO SOMETHING!”

If the product makes your skin feel itchy, it can mean that your Magnesium levels are extremely low. Itchiness is often a side effect when magnesium deficient skin is first introduced to Magnesium Oil. This “urgency reaction” causes the blood vessels to open quickly, creating friction under the skin. This sensation and other side effects should subside when the product is used consistently, and the body no longer has the “urgency reaction”. It can also be caused by the small amount of salt residue left on your skin.

How to Use: Start by using just a few sprays on your skin; initially no more than five. Over the next few days, gradually work up to 10-20 sprays a day. It is also wise to do a patch test on your skin (particularly if you have sensitive skin) before applying the spray all over your body. A lot of people may initially experience tingling or a slight itching sensation where the oil is applied. This can be relieved by applying aloe vera on the site or coconut oil about 20 minutes after applying the oil (to give it a chance to absorb properly).

EFFECTIVESS OF TOPICAL ANALGESIC

Whether you suffer from arthritis pain, are an athlete looking to find relief from an injury, or you tweaked your knee doing yard work – chances are you’ve probably reached for a bottle of topical pain relief before. These over-the-counter products are applied directly to the skin and come in gels, creams, sprays and patches.

When it comes to relieving the pain of achy joints, many people reach for a pain-relieving pill like aspirin or ibuprofen. There may be a better way. When the source of pain is close to the surface, applying a cream, gel, patch, or spray that contains a pain reliever right where it hurts can ease pain and help avoid some of the body-wide side effects of oral pain relievers.

The active ingredient in most topical analgesics is a nonsteroidal anti-inflammatory drug (NSAID) like ibuprofen, naproxen, aspirin, or diclofenac. These medications target inflammation, which contributes to pain, swelling, and stiffness.

We know that oral NSAIDs can quell arthritis pain. Do they work as well when applied to the skin? A scientific review by the Cochrane Collaboration, an international body of health experts, found that some prescription topical NSAIDs can offer the same pain relief as oral medications with fewer gastrointestinal concerns.

The advantage of using a topical analgesic is that the medication works locally. Targeting pain more precisely using a medication applied to the skin can help skirt the side effects of oral drugs or unwanted medical residues that may damage kidneys, livers or stomach linings. This can be a boon for people whose stomachs are sensitive to NSAIDs. Other people seek topical NSAIDs because they want to avoid adding another pill to their daily regimen, or have trouble taking pills.

HOW OUR PRODUCTS WORK

Thai Remedies Products are skincare products with  an analgesic effect that is useful for skin health but also for treating not only sprains and sore muscles, but also arthritis and other types of joint pain.  The fast acting, menthol or cayenne pepper-based formula of our products provide you powerful pain relief when directly applied as target spot therapy to the skin. Pain happens when your receptors send a signal from your spine to your brain. Cold sensations, like menthol, stimulate receptors to block those signals to relieve pain.

Our products come in gel, spray, cream or roll-on form, and is a type of cryotherapy (cold therapy) and thermotherapy (hot therapy).  Its active ingredient is menthol (from the mint family of plants), which causes your brain to interpret the nerve signals being sent as a sensation of cold, triggering a reduction in inflammation, or capsaicin (from the red ginger and cayenne pepper family of plants), which will sooth the skin with it warmness, and open up the skin surface to relax, and deep soothing the skin with circulation and oxygen, then triggering a reduction in inflammation and resulting in breaking up the pain signal and affected the Substance P, reduce swelling and it does reduce pain with it coolness or warmness.

Both our hot and cold skincare formula  with analgesic effect work by causing ligand molecules to attach themselves to your nerve’s cold receptors, which effectively helps to bring coolness or warmness to the area, interfering with pain signals traveling to the brain.  Its menthol or cayenne also induces vasodilation, which increases blood flow to the injured area, allowing cellular waste products to be swept away more efficiently and for healing oxygen and nutrients to be delivered to the cells.

Other herbal ingredients included, Thai Plai, Ginger, Turmeric, Arnica, Calendula, Aloe, Boswellia, Willow Bark, Green Tea, Burdock, Lemon Balm and vitamin E.  All of these have been used for centuries in treating tissue injuries such as bruises, sprains and strains.  Camphor, another ingredient in our products, has both numbing and antiseptic properties.

WHY OUR PRODUCT IS SO EFFECTIVE?

Our product is so effective, simply because it doesn’t numb the area, but its long lasting effect of coolness or warmness it really bring healing from the top of the skin layer to the deepest, where other products numb the area (instead of the sensation of cooling, warming, tingling, itching, ..these are the signs that the ingredients are working for you, by blocking the pain sensory, create oxygen flow, bring circulation, break up scar tissue, and bring soothing feeling to the target spot in need) but doesn’t bring a full cycle of  healing of reduction swelling, inflammation and pain. It doesn’t make sense to just apply something to numb the skin, to stop the pain cycle, when the body actually need to reset, rebuild and restore its optimal functions.

USING A TOPICAL ANALGESIC

Topical analgesics can be applied two to four times a day to control mild to moderate pain. Make sure to wash your hands thoroughly after use so you don’t smear the drug into your eyes, nose, mouth, or other mucous membranes.

Side effects from topical medications include redness, itching, and other skin irritation. They are generally mild—and uncommon. Please always perform patch test to find out your tolerances.

NOTE: A key warning about using topical analgesics: don’t use them if you are also taking an oral NSAID—either prescription or over-the-counter—without telling your doctor. Taking too much of an NSAID can land you in the hospital with stomach bleeding or an ulcer flare-up. In fact, up to 100,000 Americans are hospitalized every year for NSAID-related gastrointestinal problems.

Q: What ingredients are in topical pain relievers and how do they work?

A: Over-the-counter topical pain relievers often include methyl salicylate (also known as oil of wintergreen). This ingredient gives topical pain relievers that minty smell and creates a cooling sensation when applied to the skin.

Methyl salicylate is often used as counterirritant, which basically acts as a distraction to pain points. Depending on the product and the other ingredients in it, these rub on treatments may also contain a non-steroidal anti-inflammatory drug (NSAID). You know NSAIDs from medicines like ibuprofen and aspirin. When it’s absorbed into the skin it can decrease the inflammatory reaction. Some topical pain relievers also contain capsaicin, which is a compound found in chili peppers and is responsible for producing a warming sensation. 

Other products may contain menthol, also known as mint camphor, which causes a cooling sensation and can trick the mind into thinking that the skin or body temperature is dropping. In return, this cooling feeling desensitizes the nerve endings. Like ice or cold packs, menthol decreases arterial blood flow.

Q: Why would someone use a topical pain reliever?

A: Topical pain relievers work best on acute musculoskeletal pain, rather than chronic pain. So if you have a nagging sore neck or pulled a muscle in your shoulder, you might benefit from slathering on a layer. These products are also used to treat:

• Minor aches and pains.
• Pulled or sore muscles.
• Sprains and strains.
• Discomfort and pain associated with cancer has also been shown to improve from topical pain relievers.

Q: Gels, creams, sprays, roll ons or patches – what’s best?

A: It all comes down to personal preference, but it’s important to review the active ingredients in each product. If you’re looking for an easy-to-apply spray that contains capsaicin, it might only come in a gel form. So read the label and decide what you’re looking for first.

A patch typically works well on an area where it can be applied to a flat surface, so it might be best to reach for this product with back or neck pain. On the other hand, a cream or gel might be best for a sore elbow or knee so that the joint can still move and bend.

Q: Can topical pain relievers be dangerous?

A: It’s important to use these products as directed. Although it’s extremely rare, there have been instances where overuse and misuse has led to serious side effects and even death due to salicylate poisoning.

Never mix these products with heat, such as from a heating pad. Doing so could cause the product to be absorbed into the blood stream at a faster rate. If you use a topical pain reliever be sure to:

• Read the label carefully before applying the product.
• Do not apply to open wounds or skin that is already injured or irritated.
• Do not apply near your eyes or genitals.
• Do not use with heat, especially a heating pad or hot water.
• Stop use if you develop a rash and tell your doctor.
• If the burning sensation is too painful and uncomfortable, use a towel to remove the product from your skin.
• Experts recommend to not use topical pain relievers (of any kind) if you’re pregnant.

Q: At what point should you stop using a topical pain reliever and see a doctor

A: Most topical pain relievers should not be used over seven days. Using it for longer than directed could result in a rash or sometimes even a chemical burn. Stop use if your condition worsens or the area becomes irritated.

If your stubborn pain just won’t quit, it might be time to bring in the big guns and talk with your doctor. He or she can help you solve the problem of your nagging pain and might even prescribe a prescription based topical pain reliever.